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Article Dans Une Revue World Neurosurgery Année : 2018

Ventricular Volume Dynamics During the Development of Adult Chronic Communicating Hydrocephalus in a Rodent Model

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Tito Vivas-Buitrago
  • Fonction : Auteur
Gabriel Pinilla-Monsalve
  • Fonction : Auteur
Ignacio Jusue-Torres
  • Fonction : Auteur
Kumiko Oishi
  • Fonction : Auteur
Jamie Robison
  • Fonction : Auteur
Joshua A. Crawford
  • Fonction : Auteur
Mikhail Pletnikov
  • Fonction : Auteur
Jiadi Xu
  • Fonction : Auteur
Armelle Lokossou
  • Fonction : Auteur
Alice L. Hung
  • Fonction : Auteur
Ari M. Blitz
  • Fonction : Auteur
Jennifer Lu
  • Fonction : Auteur
Daniel A. Herzka
  • Fonction : Auteur
Hugo Guerrero-Cazares
  • Fonction : Auteur
Kenichi Oishi
  • Fonction : Auteur
Susumu Mori
  • Fonction : Auteur
Alfredo Quinones-Hinojosa
  • Fonction : Auteur
Daniele Rigamonti
  • Fonction : Auteur

Résumé

INTRODUCTION: The pathophysiology of normal-pressure hydrocephalus and the correlation with its symptomatology is not well understood. OBJECTIVE: To monitor and evaluate the enlargement patterns of the ventricular system for each ventricle and its correlation with the presenting symptoms. METHODS: Bilateral kaolin injection into the subarachnoid space overlying the cranial convexities was done in 18 adult rats. Magnetic resonance imaging was performed on an 11.7-T scanner 15, 60, 90, and 120 days after injection. Volumes of the ventricular system were measured for each ventricle and correlated with biweekly behavioral findings. RESULTS: There was a progressive increase in the ventricular volume for the lateral ventricles since day 15 in the kaolin-injected animals. There was a nonsignificant trend in volume growth for the third ventricle, but its enlargement was synchronous with the lateral ventricles. No significant change for the fourth ventricle. No symptoms were detected in the first 60 days. Association was found between the ventricular volume and locomotor changes. In addition, the odds of locomotor symptoms increased by 3% for every additional cubic millimeter of volume in the left (P< 0.001) and right (P = 0.023) ventricles, and for the total magnetic resonance imaging volume by 1% (P = 0.013). CONCLUSIONS: Expansion of the lateral ventricles maintained similar proportions over time, accompanied by a synchronous third ventricular expansion with less proportion and a nonsignificant fourth enlargement. Lateral ventricles enlarged most in those animals that were to develop late locomotor deterioration. Further research using this animal model combined with different radiologic imaging techniques, such as diffusion tensor imaging and perfusion studies, is recommended.
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hal-03599026 , version 1 (06-03-2022)

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Tito Vivas-Buitrago, Gabriel Pinilla-Monsalve, Ignacio Jusue-Torres, Kumiko Oishi, Jamie Robison, et al.. Ventricular Volume Dynamics During the Development of Adult Chronic Communicating Hydrocephalus in a Rodent Model. World Neurosurgery, 2018, 120, pp.E1120-E1127. ⟨10.1016/j.wneu.2018.08.241⟩. ⟨hal-03599026⟩

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