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A prospective multicentre REFCOR study of 470 cases of head and neck Adenoid cystic carcinoma: epidemiology and prognostic factors

Sarah Atallah 1 Odile Casiraghi 2, 3 Nicolas Fakhry 4, 5 Michel Wassef 6 Emmanuelle Uro-Coste 7 Florent Espitalier 8 Anne Sudaka 9 Marie Christine Kaminsky 10 Stéphanie Dakpé 11, 12 Laurence Digue 13 Olivier Bouchain Sylvain Moriniere 14 Muriel Hourseau 15 Chloe Bertolus 16 Franck Jegoux 17 Juliette Thariat 18 Valentin Calugaru 6 Philippe Schultz 19 Pierre Philouze 20 Olivier Mauvais 21 Christian A. Righini Cecile Badoual 22 Nicolas Saroul 23 Jean Michel Goujon 24 Jean Paul Marie 25, 26, 27, 28 Rabah Taouachi 6 Esteban Brenet 29 Anne Auperin 30 Bertrand Baujat 31 
3 Génétique (Biologie pathologie)
Département de biologie et pathologie médicales [Gustave Roussy]
Abstract : Background: Adenoid cystic carcinoma (ACC) accounts for 1% of malignant head and neck tumours [1] and 10% of salivary glands malignant tumours. The main objective of our study is to investigate the prognostic factors influencing the event-free survival (EFS) of patients with ACC. Patients and methods: A multicentre prospective study was conducted from 2009 to 2018. All 470 patients with ACC whose survival data appear in the REFCOR database were included in the study. The main judgement criterion was EFS. Both a bivariate survival analysis using log-rank test and a multivariate using Cox model were performed using the R software. Results: Average age was 55 years. Females accounted for 59.4% of the cohort. The body mass index (BMI) was normal in 86% of cases. Tumours were located in minor salivary glands in 60% of cases. T3/T4 stages represented 58%; 89% of patients were cN0. histological grade III was observed on 21% of patients. The EFS and overall 5-year survival rates were 50% and 85%, respectively. After adjustment, the most significant pejorative prognostic factors were age >= 65 years (hazard ratio [HR] = 1.67), BMI<16.5 (HR = 2.62), and lymph node invasion cN (HR = 2.08). Conclusion: Age, BMI and N stage are the three main clinical prognostic factors determining EFS identified in this prospective series of patients with ACC. Such findings open new research perspectives on the influence of these components on initial patient care. (C) 2020 Elsevier Ltd. All rights reserved.
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Soumis le : dimanche 6 mars 2022 - 15:58:41
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Sarah Atallah, Odile Casiraghi, Nicolas Fakhry, Michel Wassef, Emmanuelle Uro-Coste, et al.. A prospective multicentre REFCOR study of 470 cases of head and neck Adenoid cystic carcinoma: epidemiology and prognostic factors. European journal of cancer, Elsevier, 2020, 130, pp.241-249. ⟨10.1016/j.ejca.2020.01.023⟩. ⟨hal-03599053⟩



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