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Article Dans Une Revue European journal of cancer Année : 2020

A prospective multicentre REFCOR study of 470 cases of head and neck Adenoid cystic carcinoma: epidemiology and prognostic factors

1 Oto-Rhino-Laryngologie Chirurgie cervico-faciale [CHU Tenon]
2 IGR - Institut Gustave Roussy
3 Génétique (Biologie pathologie)
4 LPL - Laboratoire Parole et Langage
5 APHM - Assistance Publique - Hôpitaux de Marseille
6 Institut Curie [Paris]
7 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole
8 CHU Nantes - Centre hospitalier universitaire de Nantes
9 IBV - Institut de Biologie Valrose
10 UNICANCER/ICL - Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy]
11 CHU Amiens-Picardie
12 CHIMERE - CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516
13 Hôpital Pellegrin
14 Service ORL et chirurgie cervico-faciale [Tours]
15 Service d'Anatomopathologie [Bichat - Claude Bernard]
16 CHU Pitié-Salpêtrière [AP-HP]
17 COSS - Chemistry, Oncogenesis, Stress and Signaling
18 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
19 CHU Strasbourg
20 HCL - Hospices Civils de Lyon
21 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
22 PARCC (UMR_S 970/ U970) - Paris-Centre de Recherche Cardiovasculaire
23 Service de Chirurgie Maxillo-Faciale et Chirurgie Plastique [CHU Clermont-Ferrand]
24 IRTOMIT - Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques
25 GRHV - Groupe de Recherche sur le Handicap Ventilatoire
26 Service d'ORL, chirurgie cervico-faciale [Rouen]
27 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
28 IRIB - Institute for Research and Innovation in Biomedicine
29 CHU Reims - Centre Hospitalier Universitaire de Reims
30 SBE - Service de biostatistique et d'épidémiologie
31 CHU Tenon [AP-HP]
Florent Espitalier
  • Fonction : Auteur
  • PersonId : 1034920
Anne Sudaka
Olivier Bouchain
  • Fonction : Auteur
Valentin Calugaru
Philippe Schultz
  • Fonction : Auteur
Christian A. Righini
  • Fonction : Auteur

Résumé

Background: Adenoid cystic carcinoma (ACC) accounts for 1% of malignant head and neck tumours [1] and 10% of salivary glands malignant tumours. The main objective of our study is to investigate the prognostic factors influencing the event-free survival (EFS) of patients with ACC. Patients and methods: A multicentre prospective study was conducted from 2009 to 2018. All 470 patients with ACC whose survival data appear in the REFCOR database were included in the study. The main judgement criterion was EFS. Both a bivariate survival analysis using log-rank test and a multivariate using Cox model were performed using the R software. Results: Average age was 55 years. Females accounted for 59.4% of the cohort. The body mass index (BMI) was normal in 86% of cases. Tumours were located in minor salivary glands in 60% of cases. T3/T4 stages represented 58%; 89% of patients were cN0. histological grade III was observed on 21% of patients. The EFS and overall 5-year survival rates were 50% and 85%, respectively. After adjustment, the most significant pejorative prognostic factors were age >= 65 years (hazard ratio [HR] = 1.67), BMI<16.5 (HR = 2.62), and lymph node invasion cN (HR = 2.08). Conclusion: Age, BMI and N stage are the three main clinical prognostic factors determining EFS identified in this prospective series of patients with ACC. Such findings open new research perspectives on the influence of these components on initial patient care. (C) 2020 Elsevier Ltd. All rights reserved.
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Dates et versions

hal-03599053 , version 1 (06-03-2022)

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Sarah Atallah, Odile Casiraghi, Nicolas Fakhry, Michel Wassef, Emmanuelle Uro-Coste, et al.. A prospective multicentre REFCOR study of 470 cases of head and neck Adenoid cystic carcinoma: epidemiology and prognostic factors. European journal of cancer, 2020, 130, pp.241-249. ⟨10.1016/j.ejca.2020.01.023⟩. ⟨hal-03599053⟩
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