Ferroptosis in Liver Disease

Antoine Galmiche (1, 2)

1 CHIMERE - CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516
2 CHU Amiens-Picardie

Ferroptosis, a form of non-apoptotic regulated cell death characterized by its dependence on cellular iron availability and the occurrence of intense lipid peroxidation, was first described in 2012. Over the past 7 years, a number of biomarkers and candidate regulatory genes of ferroptosis have been identified. In spite of this increasing fundamental knowledge, little is known regarding the induction of ferroptosis in vivo. Here, we review the studies that address the possibility that ferroptosis could contribute to the spectrum of liver diseases, acute or chronic. We also discuss the appealing possibility of inducing ferroptosis as a therapeutic approach against hepatocellular carcinoma, the most frequent form of primary liver cancer.

Domaines: Sciences du Vivant [q-bio]

Antoine Galmiche. Ferroptosis in Liver Disease. Tang, D. FERROPTOSIS IN HEALTH AND DISEASE, pp.239-248, 2019, 978-3-030-26780-3; 978-3-030-26779-7. ⟨10.1007/978-3-030-26780-3\_13⟩. ⟨hal-03599306⟩