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Testicular germ-cell tumours and penile squamous cell carcinoma: Appropriate management makes the difference

Nicola Nicolai Davide Biasoni Mario A. Catanzaro Maurizio Colecchia Monika Hackl Elizabeth van Eycken Kris Henau Nadya Dimitrova Mario Sekerija Ladislav Dusek Margit Magi Nea Malila Maarit Leinonen Michel Velten Xavier Troussard Veronique Bouvier Anne-Valerie Guizard Anne -Marie Bouvier Patrick Arveux Marc Maynadie Anne-Sophie Woronoff Michel Robaszkiewicz Isabelle Baldi Alain Monnereau Brigitte Tretarre Marc Colonna Florence Molinie Simona Bara Claire Schvartz Bénédicte Lapôtre-Ledoux 1 Pascale Grosclaude Roland Stabenow Sabine Luttmann Alice Nennecke Jutta Engel Gabriele Schubert-Fritschle Jan Heidrich Bernd Holleczek Jon Gunnlaugur Jonasson Kerri Clough-Gorr Harry Comber Guido Mazzoleni Adriano Giacomin Antonella Sutera Sardo Alessandro Barchielli Diego Serraino Roberta de Angelis Sandra Mallone Andrea Tavilla Daniela Pierannunzio Silvia Rossi Mariano Santaquilani Arnold Knijn Fabio Pannozzo Valerio Gennaro Lucia Benfatto Paolo Ricci Mariangela Autelitano Gianbattista Spagnoli Mario Fusco Mario Usala Francesco Vitale Maria Michiara Rosario Tumino Lucia Mangone Fabio Falcini Stefano Ferretti Rosa Angela Filiberti Enza Marani Arturo Iannelli Flavio Sensi Silvano Puffer Maria Gentilini Anselmo Madeddu Antonio Ziino Sergio Maspero Pina Candela Fabrizio Stracci Giovanna Tagliabue Massimo Rugge Annalisa Trama Gemma Gatta Laura Botta Riccardo Capocaccia Santa Pildava Giedre Smailyte Neville Calleja Tom Berge Johannesen Jadwiga Rachtan Stanislaw Gozdz Jerzy Blaszczyk Kamila Kepska Goncalo Forjaz De Lacerda Maria Jose Bento Ana Miranda Chakameh Safaei Diba Enrique Almar Nerea Larranaga Arantza Lopez De Munain Ma Torrella-Ramos Jose Maria Diaz Garcia Rafael Marcos-Gragera Maria Jose Sanchez Carmen Navarro Diego Salmeron Conchi Moreno-Iribas Jaume Galceran Maria Carulla Mohsen Mousavi Christine Bouchardy Silvia M. Ess Andrea Bordoni Isabelle Konzelmann Jem Rashbass Anna Gavin David H. Brewster Dyfed Wyn Huws Otto Visser Magdalena Bielska-Lasota Maja Primic-Zakelj Ian Kunkler Ellen Benhamou 
Abstract : Germ-cell tumours (GCT) of the testis and penile squamous cell carcinoma (PeSCC) are a rare and a very rare uro-genital cancers, respectively. Both tumours are well defined entities in terms of management, where specific recommendations - in the form of continuously up-to-dated guide lines-are provided. Impact of these tumour is relevant. Testicular GCT affects young, healthy men at the beginning of their adult life. PeSCC affects older men, but a proportion of these patients are young and the personal consequences of the disease may be devastating. Deviation from recommended management may be a reason of a significant prognostic worsening, as proper treatment favourably impacts on these tumours, dramatically on GCT and significantly on PeSCC. RARECAREnet data may permit to analyse how survivals may vary according to geographical areas, histology and age, leading to assume that non-homogeneous health-care resources may impact the cure and definitive outcomes. In support of this hypothesis, some epidemiologic datasets and clinical findings would indicate that survival may improve when appropriate treatments are delivered, linked to a different accessibility to the best health institutions, as a consequence of geographical, cultural and economic barriers. Finally, strong clues based on epidemiological and clinical data support the hypothesis that treatment delivered at reference centres or under the aegis of a qualified multi-institutional network is associated with a better prognosis of patients with these malignancies. The ERN EURACAN represents the best current European effort to answer this clinical need. (C) 2018 Published by Elsevier Ltd.
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Soumis le : lundi 7 mars 2022 - 16:42:57
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Nicola Nicolai, Davide Biasoni, Mario A. Catanzaro, Maurizio Colecchia, Monika Hackl, et al.. Testicular germ-cell tumours and penile squamous cell carcinoma: Appropriate management makes the difference. EJSO - European Journal of Surgical Oncology, WB Saunders, 2019, 45 (1, SI), pp.60-66. ⟨10.1016/j.ejso.2018.02.006⟩. ⟨hal-03600615⟩



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