Targeting coagulation to unlock antitumor immunity?

Antoine Galmiche (1, 2) , Zuzana Saidak (1, 2) , Francois Ghiringhelli (3)

1 CHIMERE - CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516
2 CHU Amiens-Picardie
3 UNICANCER/CAL - Centre de Lutte contre le Cancer Antoine Lacassagne [Nice]

Besides a number of physical consequences (reduced blood supply, stabilization of circulating tumor microemboli, shielding from the attack of immune cells), the coagulation cascade may specifically regulate antitumor immunity. We recently applied systems biology and genomics to explore the regulation of the tumor immune microenvironment by coagulation.

Domaines: Sciences du Vivant [q-bio]

Antoine Galmiche, Zuzana Saidak, Francois Ghiringhelli. Targeting coagulation to unlock antitumor immunity?. Oncoimmunology, 2022, 11 (1), ⟨10.1080/2162402X.2022.2045696⟩. ⟨hal-03603772⟩