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Article Dans Une Revue Médecine Intensive Réanimation Année : 2019

Warburg Effect: a Diagnostic Challenge for Clinicians

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Résumé

The Warburg effect is a common and serious complication at the onset or during the management of solid neoplasms or haematological malignancies. It is due to a specific malignant-cell metabolism, where lactic fermentation predominates over oxidative phosphorylation regardless of the oxygen level, leading to some degree of lactate accumulation with type-B lactic acidosis and asymptomatic hypoglycaemia. Since the diagnosis of Warburg effect is a challenge, we propose an algorithm to help clinicians and discuss its treatment.
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Dates et versions

hal-03605013 , version 1 (10-03-2022)

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C. Brault, J. Marc, C. Delette, B. Gruson, J-P Marolleau, et al.. Warburg Effect: a Diagnostic Challenge for Clinicians. Médecine Intensive Réanimation, 2019, 28 (6), pp.435-442. ⟨10.3166/rea-2019-0129⟩. ⟨hal-03605013⟩
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