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Gastrointestinal emergencies in critically ill cancer patients

Abstract : Purpose: To describe gastrointestinal emergencies in cancer patients. Methods: All cancer patients admitted to the medical ICU of Saint-Louis Hospital for an acute abdominal syndrome during the study period (1997-2011) were included. Results: A total of 164 patients were included. The most common diagnoses were: neutropenic enterocolitis (NE) (n = 54, 33%), infectious colitis and peritonitis (n = 51, 31%), bowel infiltration by malignancy (n = 14, 9%), and mucosal toxicity of chemotherapy (n = 12, 7%). Microbiologically documented infections were reported in 82 patients (50%), including 12 fungal infections. Twenty-seven patients (16%) underwent urgent surgery. The hospital mortality rate was 35%. Five factors were independently associated with hospital mortality: the Simplified Acute Physiology Score II (SAPS II) score on day 1 (OR 1.03/SAPS II point, 95% CI 1.01 to 1.05), microbiological documentation (OR 0.27, 95% CI 0.11 to 0.64), neutropenia (OR 0.42, 95% CI 0.19 to 0.95), allogenic hematopoietic stem-cell transplantation (HSCT) (OR 5.13, 95% CI 1.71 to 15.4), and mechanical ventilation (OR 3.42, 95% CI 1.37 to 8.51). Conclusions: Gastrointestinal emergencies in cancer patients are associated with significant mortality. Mortality correlated both with the severity of organ failure upon ICU admission and the underlying diagnosis. Interestingly, patients admitted to the ICU with neutropenia had better survival. (C) 2017 Elsevier Inc. All rights reserved.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03606397
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Soumis le : vendredi 11 mars 2022 - 17:44:17
Dernière modification le : samedi 12 mars 2022 - 03:33:58

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Delphine Lebon, Lucie Biard, Sophie Buyse, David Schnell, Etienne Lengline, et al.. Gastrointestinal emergencies in critically ill cancer patients. Journal of critical care, 2017, 40, pp.69-75. ⟨10.1016/j.jcrc.2017.03.015⟩. ⟨hal-03606397⟩

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