Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Neurology Année : 2019

Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups

, , , (1) , (2) , , (3) , (3) , (4) , , , , , , , , (5) , (6) , (1) , , , , , , (7) , (3) , (8) , (9) , (10) , (11) , (12) , (11) , , , (3) , , (13) , (14) , , , (15) , (11) , (16)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
Jessica W. Lo
  • Fonction : Auteur
John D. Crawford
  • Fonction : Auteur
David W. Desmond
  • Fonction : Auteur
Simin Mahinrad
  • Fonction : Auteur
Elles Douven
  • Fonction : Auteur
Julie Staals
  • Fonction : Auteur
Christopher Chen
  • Fonction : Auteur
Xin Xu
  • Fonction : Auteur
Eddie J. Chong
  • Fonction : Auteur
Rufus O. Akinyemi
  • Fonction : Auteur
Rajesh N. Kalaria
  • Fonction : Auteur
Melanie Barbay
Byung-Chul Lee
  • Fonction : Auteur
Velandai K. Srikanth
  • Fonction : Auteur
Christopher Moran
  • Fonction : Auteur
Nagaendran Kandiah
  • Fonction : Auteur
Russell J. Chander
  • Fonction : Auteur
Timo Erkinjuntti
  • Fonction : Auteur
Darren M. Lipnicki
  • Fonction : Auteur
Nicole A. Kochan
  • Fonction : Auteur
Amy Brodtmann
  • Fonction : Auteur
Michael Hoffmann
Thomas Linden
  • Fonction : Auteur

Résumé

Objective To address the variability in prevalence estimates and inconsistencies in potential risk factors for poststroke cognitive impairment (PSCI) using a standardized approach and individual participant data (IPD) from international cohorts in the Stroke and Cognition Consortium (STROKOG) consortium. Methods We harmonized data from 13 studies based in 8 countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standardized cognitive domain scores. Domain-specific impairment was based on percentile cutoffs from normative groups, and associations between domain scores and risk factors were examined with 1-stage IPD meta-analysis. Results In a combined sample of 3,146 participants admitted to hospital for stroke (97%) or TIA (3%), 44% were impaired in global cognition and 30% to 35% were impaired in individual domains 2 to 6 months after the index event. Diabetes mellitus and a history of stroke were strongly associated with poorer cognitive function after covariate adjustments; hypertension, smoking, and atrial fibrillation had weaker domain-specific associations. While there were no significant differences in domain impairment among ethnoracial groups, some interethnic differences were found in the effects of risk factors on cognition. Conclusions This study confirms the high prevalence of PSCI in diverse populations, highlights common risk factors, in particular diabetes mellitus, and points to ethnoracial differences that warrant attention in the development of prevention strategies.

Dates et versions

hal-03606869 , version 1 (12-03-2022)

Identifiants

Citer

Jessica W. Lo, John D. Crawford, David W. Desmond, Olivier Godefroy, Hanna Jokinen, et al.. Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups. Neurology, 2019, 93 (24), pp.E2257-E2271. ⟨10.1212/WNL.0000000000008612⟩. ⟨hal-03606869⟩
14 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook Twitter LinkedIn More