Cross-validation of a Shortened Battery for the Assessment of Dysexecutive Disorders in Alzheimer Disease

Olivier Godefroy; Olivier Martinaud; Marc Verny; Chrystele Mosca; Hermine Lenoir; Eric Bretault; Agnes Devendeville; Momar Diouf; Jean-Jacques Pere; Serge Bakchine; Jean-Philippe Delabrousse-Mayoux; Martine Roussel

doi:10.1097/WAD.0000000000000112

Article dans une revue

Cross-validation of a Shortened Battery for the Assessment of Dysexecutive Disorders in Alzheimer Disease

Olivier Godefroy ¹ Olivier Martinaud ² Marc Verny ^{3, 4} Chrystele Mosca ^{5, 6} Hermine Lenoir ⁷ Eric Bretault Agnes Devendeville Momar Diouf ⁸ Jean-Jacques Pere ⁹ Serge Bakchine ¹⁰ Jean-Philippe Delabrousse-Mayoux Martine Roussel ¹

1 LNFP - Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559

2 Service de neurologie [Rouen]

3 B2A - Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing

4 Service de Médecine Gériatrique [CHU Pitié-Salpêtrière]

5 CHU - Centre Hospitalier Universitaire [Grenoble]

6 LNPEE - Laboratoire de physiopathologie de l'épilepsie

7 URP_4468 - Maladie d'Alzheimer : marqueurs génétiques et vasculaires, neuropsychologies

8 CHU Amiens-Picardie

9 Recherche clinique

10 URCA - Université de Reims Champagne-Ardenne

Abstract : The frequency of executive disorders in mild-to-moderate Alzheimer disease (AD) has been demonstrated by the application of a comprehensive battery. The present study analyzed data from 2 recent multicenter studies based on the same executive battery. The objective was to derive a shortened battery by using the GREFEX population as a training dataset and by cross-validating the results in the REFLEX population. A total of 102 AD patients of the GREFEX study (MMSE= 23.2 +/- 2.9) and 72 patients of the REFLEX study (MMSE= 20.8 +/- 3.5) were included. Tests were selected and receiver operating characteristic curves were generated relative to the performance of 780 controls from the GREFEX study. Stepwise logistic regression identified 3 cognitive tests (Six Elements Task, categorical fluency and Trail Making Test B error) and behavioral disorders globally referred as global hypoactivity (P= 0.0001, all). This shortened battery was as accurate as the entire GREFEX battery in diagnosing dysexecutive disorders in both training group and the validation group. Boot-strap procedure confirmed the stability of AUC. A shortened battery based on 3 cognitive tests and 3 behavioral domains provides a high diagnosis accuracy of executive disorders in mild-to-moderate AD.

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Article dans une revue

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Sciences du Vivant [q-bio]

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https://hal-u-picardie.archives-ouvertes.fr/hal-03606888
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Soumis le : samedi 12 mars 2022 - 14:19:27
Dernière modification le : mercredi 4 mai 2022 - 16:14:02

Cross-validation of a Shortened Battery for the Assessment of Dysexecutive Disorders in Alzheimer Disease

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