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Cross-validation of a Shortened Battery for the Assessment of Dysexecutive Disorders in Alzheimer Disease

Abstract : The frequency of executive disorders in mild-to-moderate Alzheimer disease (AD) has been demonstrated by the application of a comprehensive battery. The present study analyzed data from 2 recent multicenter studies based on the same executive battery. The objective was to derive a shortened battery by using the GREFEX population as a training dataset and by cross-validating the results in the REFLEX population. A total of 102 AD patients of the GREFEX study (MMSE= 23.2 +/- 2.9) and 72 patients of the REFLEX study (MMSE= 20.8 +/- 3.5) were included. Tests were selected and receiver operating characteristic curves were generated relative to the performance of 780 controls from the GREFEX study. Stepwise logistic regression identified 3 cognitive tests (Six Elements Task, categorical fluency and Trail Making Test B error) and behavioral disorders globally referred as global hypoactivity (P= 0.0001, all). This shortened battery was as accurate as the entire GREFEX battery in diagnosing dysexecutive disorders in both training group and the validation group. Boot-strap procedure confirmed the stability of AUC. A shortened battery based on 3 cognitive tests and 3 behavioral domains provides a high diagnosis accuracy of executive disorders in mild-to-moderate AD.
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Soumis le : samedi 12 mars 2022 - 14:19:27
Dernière modification le : mercredi 24 août 2022 - 10:34:24



Olivier Godefroy, Olivier Martinaud, Marc Verny, Chrystele Mosca, Hermine Lenoir, et al.. Cross-validation of a Shortened Battery for the Assessment of Dysexecutive Disorders in Alzheimer Disease. Alzheimer Disease and Associated Disorders, Lippincott, Williams & Wilkins, 2016, 30 (2), pp.140-144. ⟨10.1097/WAD.0000000000000112⟩. ⟨hal-03606888⟩



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