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Production of TNF-alpha ex vivo is predictive of an immune response to flu vaccination in a frail elderly population

Abstract : Objective: To investigate the relationship between the response to influenza vaccination and the ability to produce proinflamatory cytokines in elderly subjects. Methods: Whole blood samples from 25 elderly subjects collected before influenza vaccination were stimulated with the influenza vaccine in order to evaluate the secretion of five specific cytokines: TNF alpha, IFN alpha, IFN gamma, IL2 and IL10. The results were correlated with the increased HAI antibody titres two weeks after vaccination. Results: Only30% of elderly individuals seroconverted after vaccination. Although 50 to 70% of the cohort did not produce TNF alpha, IFN alpha, IFN gamma, IL2 or IL10, all of the individuals who seroconverted were able to produce TNF alpha. Furthermore production of IFN gamma, with or without production of IFN alpha/beta, was not associated with a better response to the vaccine. Conclusion: Production of TNF alpha appears to be primordial for an efficient vaccine response, and may provide a predictive marker for the humoral response to vaccination. It may also provide the basis for evaluating agents designed to rescue TNF alpha-producing cells. This study emphasises a need to rescue TNF-producing cell function.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03606924
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Soumis le : samedi 12 mars 2022 - 14:46:47
Dernière modification le : dimanche 13 mars 2022 - 03:00:14

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Frederic Bloch, Benedicte Charmeteau, Michael Tovey, Jean-Francois Meritet, Corinne Desaint, et al.. Production of TNF-alpha ex vivo is predictive of an immune response to flu vaccination in a frail elderly population. EUROPEAN CYTOKINE NETWORK, 2016, 27 (3), pp.63-67. ⟨10.1684/ecn.2016.0378⟩. ⟨hal-03606924⟩

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