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Article Dans Une Revue Molecules Année : 2020

Secondary Metabolites from Gorgonian Corals of the Genus Eunicella: Structural Characterizations, Biological Activities, and Synthetic Approaches

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Dario Matulja
  • Fonction : Auteur
Maria Kolympadi Markovic
  • Fonction : Auteur
Gabriela Ambrozic
  • Fonction : Auteur
Sandra Kraljevic Pavelic
  • Fonction : Auteur
Dean Markovic
  • Fonction : Auteur

Résumé

Gorgonian corals, which belong to the genus Eunicella, are known as natural sources of diverse compounds with unique structural characteristics and interesting bioactivities both in vitro and in vivo. This review is focused primarily on the secondary metabolites isolated from various Eunicella species. The chemical structures of 64 compounds were divided into three main groups and comprehensively presented: a) terpenoids, b) sterols, and c) alkaloids and nucleosides. The observed biological activities of depicted metabolites with an impact on cytotoxic, anti-inflammatory, and antimicrobial activities were reviewed. The most promising biological activities of certain metabolites point to potential candidates for further development in pharmaceutical, cosmetic, and other industries, and are highlighted. Total synthesis or the synthetic approaches towards the desired skeletons or natural products are also summarized.

Domaines

Chimie

Dates et versions

hal-03613833 , version 1 (18-03-2022)

Identifiants

Citer

Dario Matulja, Maria Kolympadi Markovic, Gabriela Ambrozic, Sylvain Laclef, Sandra Kraljevic Pavelic, et al.. Secondary Metabolites from Gorgonian Corals of the Genus Eunicella: Structural Characterizations, Biological Activities, and Synthetic Approaches. Molecules, 2020, 25 (1), ⟨10.3390/molecules25010129⟩. ⟨hal-03613833⟩
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