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Article Dans Une Revue World Neurosurgery Année : 2018

Acute Dementia After Deep Brain Stimulation in Parkinson Disease.


BACKGROUND: It is not clear whether cognitive adverse events can occur after subthalamic nuclei deep brain stimulation in Parkinson disease, and the putative mechanisms are poorly understood. CASE DESCRIPTION: We report on a rare case of a 68-year-old woman with Parkinson disease but no previous cognitive impairment. The day after deep brain stimulation of the subthalamic nuclei, the woman presented with new-onset dementia and acute, severe, persistent, global cognitive decline, prompting a diagnosis of Alzheimer disease. CONCLUSIONS: In patients seen in routine clinical practice, the simultaneous presence of several neurodegenerative diseases might not be uncommon. The assessment of mild cognitive impairment with a standardized method is highly recommended, a systematic 3-dimensional volumetric analysis of hippocampal structures should be part of the pre-deep brain stimulation evaluation, and cerebrospinal fluid biomarkers should be screened for if at least 1 of the 2 previously mentioned aspects is abnormal.
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Dates et versions

hal-03658201 , version 1 (03-05-2022)



Laurent Puy, Melissa Tir, Michel Lefranc, Hugo Yaïche, Olivier Godefroy, et al.. Acute Dementia After Deep Brain Stimulation in Parkinson Disease.. World Neurosurgery, 2018, 119, pp.63--65. ⟨10.1016/j.wneu.2018.07.197⟩. ⟨hal-03658201⟩
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