Uremic Toxins and Cardiovascular Risk in Chronic Kidney Disease: What Have We Learned Recently beyond the Past Findings? - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Toxins Année : 2022

Uremic Toxins and Cardiovascular Risk in Chronic Kidney Disease: What Have We Learned Recently beyond the Past Findings?

(1, 2, 3) , (4, 5) , (6)
1
2
3
4
5
6

Résumé

Patients with chronic kidney disease (CKD) have an elevated prevalence of atheromatous (ATH) and/or non-atheromatous (non-ATH) cardiovascular disease (CVD) due to an array of CKD-related risk factors, such as uremic toxins (UTs). Indeed, UTs have a major role in the emergence of a spectrum of CVDs, which constitute the leading cause of death in patients with end-stage renal disease. The European Uremic Toxin Work Group has identified over 100 UTs, more than 25 of which are dietary or gut-derived. Even though relationships between UTs and CVDs have been described in the literature, there are few reviews on the involvement of the most toxic compounds and the corresponding physiopathologic mechanisms. Here, we review the scientific literature on the dietary and gut-derived UTs with the greatest toxicity in vitro and in vivo. A better understanding of these toxins' roles in the elevated prevalence of CVDs among CKD patients might facilitate the development of targeted treatments. Hence, we review (i) ATH and non-ATH CVDs and the respective levels of risk in patients with CKD and (ii) the mechanisms that underlie the influence of dietary and gut-derived UTs on CVDs.
Fichier principal
Vignette du fichier
toxins-14-00280.pdf (554.97 Ko) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03659986 , version 1 (19-05-2022)

Licence

Paternité - CC BY 4.0

Identifiants

Citer

Carolla El Chamieh, Sophie Liabeuf, Ziad Massy. Uremic Toxins and Cardiovascular Risk in Chronic Kidney Disease: What Have We Learned Recently beyond the Past Findings?. Toxins, 2022, 14 (4), ⟨10.3390/toxins14040280⟩. ⟨hal-03659986⟩
43 Consultations
30 Téléchargements

Altmetric

Partager

Gmail Facebook Twitter LinkedIn More