STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease.

Perminder S. Sachdev (1) , Jessica W. Lo , John D. Crawford , Lisa Mellon , Anne Hickey (2) , David Williams (3) , Régis Bordet (4) , Anne-Marie Mendyk (4) , Patrick Gelé (5) , Dominique Deplanque (4) , Hee-Joon Bae (1) , Jae-Sung Lim (1) , Amy Brodtmann , Emilio Werden , Toby Cumming , Sebastian Köhler (6) , Frans R. J. Verhey , Yan-Hong Dong , Hui Hui Tan , Christopher Chen , Xu Xin (7) , Raj N. Kalaria , Louise M. Allan , Rufus O. Akinyemi , Adesola Ogunniyi (8) , Aleksandra Klimkowicz-Mrowiec (9) , Martin Dichgans (1) , Frank A. Wollenweber , Vera Zietemann (1) , Michael Hoffmann (10) , David W. Desmond , Thomas Linden , Christian Blomstrand , Björn Fagerberg , Ingmar Skoog (11) , Olivier Godefroy (12, 13, 14) , Mélanie Barbay (13, 14) , Martine Roussel (13) , Byung-Chul Lee , Kyung-Ho Yu , Joanna Wardlaw (15) , Stephen J. Makin , Fergus N. Doubal , Francesca M. Chappell , Velandai K. Srikanth , Amanda G. Thrift , Geoffrey A. Donnan , Nagaendran Kandiah , Russell J. Chander , Xuling Lin , Charlotte Cordonnier (4) , Solene Moulin (4) , Costanza Rossi (4) , Behnam Sabayan (16) , David J. Stott (1) , J. Wouter Jukema (17) , Susanna Melkas (18) , Hanna Jokinen (19) , Timo Erkinjuntti (20) , Vincent C. T. Mok , Adrian Wong , Bonnie Y. K. Lam , Didier Leys (4) , Hilde Hénon (4) , Stéphanie Bombois (4) , Darren M. Lipnicki , Nicole A. Kochan

1 Metacohorts Consortium
2 Department of Chemistry, Indiana University
3 School of Civil Engineering, The University of Queensland
4 TCDV - Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046
5 LilNCog - Lille Neurosciences & Cognition - U 1172
6 MUMC - Maastricht University Medical Centre
7 McGill University = Université McGill [Montréal, Canada]
8 University of Ibadan
9 UJ - Uniwersytet Jagielloński w Krakowie = Jagiellonian University
10 D-INFK - Department of Computer Science [ETH Zürich]
11 Institute of Neuroscience and Physiology [Göteborg]
12 Service de neurologie [Amiens]
13 LNFP - Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559
14 CHU Amiens-Picardie
15 Edin. - University of Edinburgh
16 HMS - Harvard Medical School [Boston]
17 Interuniversity Cardiology Institute Netherlands
18 HUS - Helsinki University Hospital [Finland]
19 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
20 HUCH

INTRODUCTION: The Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of vascular cognitive disorders (VCD). METHODS: Longitudinal studies with ≥75 participants who had suffered or were at risk of stroke or TIA and which evaluated cognitive function were invited to join STROKOG. The consortium will facilitate projects investigating rates and patterns of cognitive decline, risk factors for VCD, and biomarkers of vascular dementia. RESULTS: Currently, STROKOG includes 25 (21 published) studies, with 12,092 participants from five continents. The duration of follow-up ranges from 3 months to 21 years. DISCUSSION: Although data harmonization will be a key challenge, STROKOG is in a unique position to reuse and combine international cohort data and fully explore patient level characteristics and outcomes. STROKOG could potentially transform our understanding of VCD and have a worldwide impact on promoting better vascular cognitive outcomes.

Mots clés: Cohort studies; Data harmonization; International consortium; Post-stroke dementia; Small vessel disease; Vascular cognitive disorder; Vascular dementia

Domaines: Sciences du Vivant [q-bio]

Perminder S. Sachdev, Jessica W. Lo, John D. Crawford, Lisa Mellon, Anne Hickey, et al.. STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease.. Alzheimer's & dementia (Amsterdam, Netherlands), 2017, 7, pp.11--23. ⟨10.1016/j.dadm.2016.10.006⟩. ⟨hal-03669043⟩