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Article Dans Une Revue Future Medicinal Chemistry Année : 2021

A Novel Multi-Target Strategy to Attenuate the Progression of Parkinson's Disease by Diamine Hybrid AGE/ALE Inhibitor

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Résumé

Instead of a conventional `one-drug-one-target approach', this article presents a novel multi-target approach with a concept of trapping simultaneously as many detrimental factors as possible involved in the progression of Parkinson's disease. These factors include reactive carbonyl species, reactive oxygen species, Fe3+/Cu2+ and ortho-quinones (o-quinone), in particular. Different from the known multi-target strategies for Parkinson's disease, it is a sort of `vacuum cleaning' strategy. The new agent consists of reactive carbonyl species scavenging moiety and reactive oxygen species scavenging and metal chelating moiety linked by a spacer. Provided that the capacity of scavenging o-quinones is demonstrated, this type of agent can further broaden its potential therapeutic profile. In order to support this new hypothetical approach, a number of simple in vitro experiments are proposed. \textcopyright 2021 Newlands Press.
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Dates et versions

hal-03681743 , version 1 (30-05-2022)

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André Sasaki, Pascal Sonnet. A Novel Multi-Target Strategy to Attenuate the Progression of Parkinson's Disease by Diamine Hybrid AGE/ALE Inhibitor. Future Medicinal Chemistry, 2021, 13 (24), pp.2185--2200. ⟨10.4155/fmc-2021-0217⟩. ⟨hal-03681743⟩
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