Primary plasma cell leukemias displaying t(11;14) have specific genomic, transcriptional, and clinical features - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Blood Année : 2022

Primary plasma cell leukemias displaying t(11;14) have specific genomic, transcriptional, and clinical features

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Titouan Cazaubiel
  • Fonction : Auteur
Aurore Perrot
  • Fonction : Auteur
  • PersonId : 769019
  • IdRef : 139420215
Laura Do Souto Ferreira
  • Fonction : Auteur
Luka Pavageau
  • Fonction : Auteur
Margaret Macro
  • Fonction : Auteur

Résumé

Primary plasma cell leukemia (pPCL) is an aggressive form of multiple myeloma (MM) that has not benefited from recent therapeutic advances in the field. Because it is very rare and heterogeneous, it remains poorly understood at the molecular level. To address this issue, we performed DNA and RNA sequencing of sorted plasma cells from a large cohort of 90 newly diagnosed pPCL and compared with MM. We observed that pPCL presents a specific genomic landscape with a high prevalence of t(11;14) (about half) and high-risk genomic features such as del(17p), gain 1q, and del(1p32). In addition, pPCL displays a specific transcriptome when compared with MM. We then wanted to characterize specifically pPCL with t(11;14). We observed that this subentity displayed significantly fewer adverse cytogenetic abnormalities. This translated into better overall survival when compared with pPCL without t(11;14) (39.2 months vs 17.9 months, P 5 .002). Finally, pPCL with t(11;14) displayed a specific transcriptome, including differential expression of BCL2 family members. This study is the largest series of patients with pPCL reported so far.
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Dates et versions

hal-03684088 , version 1 (01-06-2022)

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Citer

Titouan Cazaubiel, Xavier Leleu, Aurore Perrot, Salomon Manier, Laure Buisson, et al.. Primary plasma cell leukemias displaying t(11;14) have specific genomic, transcriptional, and clinical features. Blood, 2022, 139 (17), pp.2666-2672. ⟨10.1182/blood.2021014968⟩. ⟨hal-03684088⟩
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