Phosphate Meeting Cholesterol\textemdash Consequences for Cardiovascular Disease in Chronic Kidney Disease?

L. Hénaut (1) , Z.A. Massy (2)

1 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517
2 CESP - Centre de recherche en épidémiologie et santé des populations

Cardiovascular disease is highly prevalent in patients with chronic kidney disease. Hyperphosphatemia is associated with subclinical atheromatosis in chronic kidney disease. Phosphate-induced endothelial dysfunction and vascular calcification are thought to be key inducers of atherosclerosis in this condition. Zhou et al. now demonstrate that phosphate promotes de novo cholesterol synthesis in vascular smooth muscle and macrophages through increased 3-hydroxy-3-methylglutaryl coenzyme A reductase activation. This observation may change current concepts of atherosclerosis development and management in chronic kidney disease. \textcopyright 2021 International Society of Nephrology

Domaines: Sciences du Vivant [q-bio]

L. Hénaut, Z.A. Massy. Phosphate Meeting Cholesterol\textemdash Consequences for Cardiovascular Disease in Chronic Kidney Disease?. 2021, 99 (6), pp.1264--1267. ⟨10.1016/j.kint.2021.02.022⟩. ⟨hal-03688465⟩