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Clinical and Imaging Determinants of Neurocognitive Disorders in Post-Acute COVID-19 Patients with Cognitive Complaints.

Abstract : BACKGROUND: Neurocognitive disorders (NCDs) are a part of the post-acute coronavirus disease (COVID-19) syndrome. No study has specifically evaluated NCDs in post-acute COVID-19 patients with cognitive complaints or their MRI determinants. OBJECTIVE: To characterize NCDs in post-acute COVID-19 patients with cognitive complaints. The secondary objectives were to assess their clinical and MRI determinants. METHODS: We included 46 patients with a post-acute COVID-19 cognitive complaint referred to the Amiens University Hospital Memory Center. They underwent a neuropsychological assessment and 36 had cerebral MRI. The G3 overall summary score was the sum of the mean z scores for the executive function, language, and action speed domains. Neuropsychological profiles were compared in a general linear model. Clinical determinants were analyzed by stepwise linear regression. White matter hyperintensities (WMH) masks were analyzed using parcel-based WMH symptom mapping to identify the locations of WMHs associated with cognitive performance. RESULTS: Repeated ANOVA showed a group effect (p\mkern1mu=\mkern1mu0.0001) due to overall lower performance for patients and a domain effect (p\mkern1mu=\mkern1mu0.0001) due to a lower (p\mkern1mu=\mkern1mu0.007) action speed score. The G3 overall summary score was significantly associated with solely the requirement for oxygen (R2\mkern1mu=\mkern1mu0.319, p\mkern1mu=\mkern1mu0.031). WHMs were associated with the G3 overall summary score in the following structures, all right-sided (p\mkern1mu<\mkern1mu0.01): superior frontal region, postcentral region, cingulum, cortico-spinal tract, inferior longitudinal fasciculus, internal capsule, and posterior segment of the arcuate fasciculus. CONCLUSION: Post-acute COVID-19 patients with cognitive complaints had NCD, with prominent action slowing, significantly associated with the acute phase oxygen requirement and a right-sided WMH structure pattern.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03692952
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Soumis le : vendredi 10 juin 2022 - 10:32:29
Dernière modification le : mardi 14 juin 2022 - 06:30:04

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Daniela Andriuta, Cherifa Si-Ahmed, Martine Roussel, Jean-Marc Constans, Malek Makki, et al.. Clinical and Imaging Determinants of Neurocognitive Disorders in Post-Acute COVID-19 Patients with Cognitive Complaints.. Journal of Alzheimer's disease : JAD, 2022, 87 (3), pp.1239--1250. ⟨10.3233/JAD-215506⟩. ⟨hal-03692952⟩

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