Lyotropic behavior of Gelucire 50/13 by XRD, Raman and IR spectroscopies according to hydration

M. El Hadri (1) , A. Achahbar , J. El Khamkhami , B. Khelifa (2) , V. Faivre , O. Abbas (3) , S. Bresson (4)

1 LPMC - Laboratoire de Physique de la Matière Condensée - UR UPJV 2081
2 LPCIA - Laboratoire de physico-chimie des interfaces et applications
3 CRA-W - Centre Wallon de Recherches Agronomiques
4 PSC - Physique des Systèmes Complexes - UR UPJV 4663

The present paper discuss the structural and vibrational properties of polyoxyethylene glycol glycerides (Gelucire 50/13) during the hydration with increasing water from 0% to 80%. The Gelucire 50/13 used as sustained release matrix forming agent in pharmaceutical applications and it was essentially studied by Small and Wide Angle X-ray Scattering (SWAXS), Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy according to the rate of hydration. The hydration behavior of this amphiphilic excipient has been investigated in the spectral range 4000–0 cm−1 in Raman spectroscopy, and 4000–600 cm−1 in FTIR. At increasing water contents Gelucire 50/13 forms successive bicontinuous to micellar supramolecular structures, and the vibrational changes were directly correlated with this conformational changes of the Gelucire structure. Overall, Raman and IR spectroscopy clearly demonstrated that the different functional groups studied could be characterized independently, allowing for the understanding of their role in Gelucire polymorphism. © 2016 Elsevier Ireland Ltd

Domaines: Matière Condensée [cond-mat]

M. El Hadri, A. Achahbar, J. El Khamkhami, B. Khelifa, V. Faivre, et al.. Lyotropic behavior of Gelucire 50/13 by XRD, Raman and IR spectroscopies according to hydration. Chemistry and Physics of Lipids, 2016, 200, pp.11-23. ⟨10.1016/j.chemphyslip.2016.05.005⟩. ⟨hal-03695691⟩