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Article dans une revue

Use of Real-Time Phase-Contrast MRI to Quantify the Effect of Spontaneous Breathing on the Cerebral Arteries.

Abstract : Quantification of the effect of breathing on the cerebral circulation provides a better mechanistic understanding of the brain's circulatory system and is important in the early diagnosis of certain neurological diseases. However, conventional cine phase-contrast (CINE-PC) MRI cannot be used in this field of study because it only provides an average cardiac cycle flow curve reconstructed from multiple cardiac cycles. Unlike CINE-PC, phase-contrast echo-planar imaging (EPI-PC) can be used to quantify the blood flow rate in "real-time" and thus assess the effect of breathing on blood flow. Here, we first used post-processing software (developed in-house) to determine the feasibility of quantifying cerebral arterial blood flow with EPI-PC (relative to CINE-PC) in 16 participants. In a second step, we developed a new time-domain method for quantifying the intensity and the phase shift of the effects of breathing on the mean flow rate, stroke volume, cardiac period and amplitude of cerebral blood flow (in 10 participants). Our results showed that EPI-PC can quantify cerebral arterial blood flow rate with much the same degree of accuracy as CINE-PC but is more strongly influenced by differences in magnetic susceptibility. We found that breathing affected the mean flow rate, stroke volume and cardiac period of cerebral arterial blood flow.
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Contributeur : Louise DESSAIVRE Connectez-vous pour contacter le contributeur
Soumis le : jeudi 16 juin 2022 - 15:07:49
Dernière modification le : vendredi 17 juin 2022 - 10:37:03

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Pan Liu, Sidy Fall, Olivier Balédent. Use of Real-Time Phase-Contrast MRI to Quantify the Effect of Spontaneous Breathing on the Cerebral Arteries.. NEUROIMAGE, 2022, pp.119361. ⟨10.1016/j.neuroimage.2022.119361⟩. ⟨hal-03697162⟩



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