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Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2020

Synergistic Activity of Clofazimine and Clarithromycin in an Aerosol Mouse Model of Mycobacterium avium Infection

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Jean-Philippe Lanoix
Cédric Joseph
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  • PersonId : 1145782
  • IdRef : 160767741
François Peltier
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  • PersonId : 1146070
Sandrine Castelain

Résumé

Infections with nontuberculous mycobacteria (NTM) have a poor prognosis in patients with underlying respiratory diseases. Clofazimine (CFZ) showed both experimental and clinical promising results against clinically relevant NTM. However, there are no data on CFZ in combination with the current recommended treatment; therefore, we aimed to study its in vivo activity in an aerosol mouse model of Mycobacterium avium . In an aerosol infection BALB/c mouse model using M. avium strain Chester, we treated 58 mice with four combinations of rifampin (RIF) at 10 mg/kg, CFZ at 25 mg/kg, and clarithromycin (CLR) and ethambutol (EMB) at 100 mg/kg.

Dates et versions

hal-03703073 , version 1 (23-06-2022)

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Jean-Philippe Lanoix, Cédric Joseph, François Peltier, Sandrine Castelain, Claire Andréjak. Synergistic Activity of Clofazimine and Clarithromycin in an Aerosol Mouse Model of Mycobacterium avium Infection. Antimicrobial Agents and Chemotherapy, 2020, 64 (5), ⟨10.1128/AAC.02349-19⟩. ⟨hal-03703073⟩
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