Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke

J. Matthijs Biesbroek (1) , Nick A. Weaver (1) , Hugo P. Aben (2) , Hugo J. Kuijf (3) , Jill Abrigo (4) , Hee-Joon Bae (5) , Melanie Barbay (6, 7, 8) , Jonathan G. Best (9) , Regis Bordet (10, 11) , Francesca M. Chappell (12) , Christopher P. L. H. Chen (13) , Thibaut Dondaine (11, 10) , Ruben S. van Der Giessen (14) , Olivier Godefroy (7, 8) , Bibek Gyanwali (13) , Olivia K. L. Hamilton (12) , Saima Hilal (15) , Irene M. C. Huenges Wajer (16) , Yeonwook Kang (17) , L. Jaap Kappelle (3) , Beom Joon Kim (5) , Sebastian Kohler (18) , Paul L. M. De Kort (2) , Peter J. Koudstaal (15) , Gregory Kuchcinski (11, 19) , Bonnie Y. K. Lam (4) , Byung-Chul Lee (20) , Keon-Joo Lee (5) , Jae-Sung Lim (20) , Renaud Lopes (11, 19) , Stephen D. J. Makin (21) , Anne-Marie Mendyk (22, 19) , Vincent C. T. Mok (4) , Mi Sun Oh (17) , Robert J. Van Oostenbrugge (23) , Martine Roussel (7, 8) , Lin Shi (4) , Julie Staals (23) , Maria del C. Valdes-Hernandez (12) , Narayanaswamy Venketasubramanian , Frans R. J. Verhey (18) , Joanna M. Wardlaw (12) , David J. Werring (9) , Xu Xin (13) , Kyung-Ho Yu (17) , Martine J. E. Van Zandvoort (16) , Lei Zhao , Geert Jan Biessels (1)

1 Utrecht Brain Center [UMC]
2 Tweesteden Hospital
3 University Medical Center [Utrecht]
4 The Chinese University of Hong Kong [Hong Kong]
5 SNUCM - Seoul National University College of Medicine [Séoul, Corée du Sud]
6 UPJV - Université de Picardie Jules Verne
7 LNFP - Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559
8 CHU Amiens-Picardie
9 IN-UCL-QS - Institute of Neurology - UCL/Queen Square [London, UK]
10 Université de Lille
11 LilNCog - Lille Neurosciences & Cognition - U 1172
12 University of Edinburgh
13 NUHS - National University Health System [Singapore]
14 Erasmus MC - Erasmus University Medical Center [Rotterdam]
15 NUS - National University of Singapore
16 Utrecht University [Utrecht]
17 Hallym University
18 Maastricht University [Maastricht]
19 CHU Lille
20 Asan Medical Center [Seoul]
21 University of Aberdeen
22 EPHE - École Pratique des Hautes Études
23 MUMC - Maastricht University Medical Centre

Background: Post-stroke cognitive impairment (PSCI) is a common consequence of stroke. Accurate prediction of PSCI risk is challenging. The recently developed network impact score, which integrates information on infarct location and size with brain network topology, may improve PSCI risk prediction. Aims: To determine if the network impact score is an independent predictor of PSCI, and of cognitive recovery or decline. Methods: We pooled data from patients with acute ischemic stroke from 12 cohorts through the Meta VCI Map consortium. PSCI was defined as impairment in & GE; 1 cognitive domain on neuropsychological examination, or abnormal Montreal Cognitive Assessment. Cognitive recovery was defined as conversion from PSCI < 3 months post-stroke to no PSCI at follow-up, and cognitive decline as conversion from no PSCI to PSCI. The network impact score was related to serial measures of PSCI using Generalized Estimating Equations (GEE) models, and to PSCI stratified according to post-stroke interval (< 3, 3-12, 12-24, > 24 months) and cognitive recovery or decline using logistic regression. Models were adjusted for age, sex, education, prior stroke, infarct volume, and study site. Results: We included 2341 patients with 4657 cognitive assessments. PSCI was present in 398/844 patients (47%) < 3 months, 709/1640 (43%) at 3-12 months, 243/853 (28%) at 12-24 months, and 208/522 (40%) > 24 months. Cognitive recovery occurred in 64/181 (35%) patients and cognitive decline in 26/287 (9%). The network impact score predicted PSCI in the univariable (OR 1.50, 95%CI 1.34-1.68) and multivariable (OR 1.27, 95%CI 1.10-1.46) GEE model, with similar ORs in the logistic regression models for specified post-stroke in-tervals. The network impact score was not associated with cognitive recovery or decline. Conclusions: The network impact score is an independent predictor of PSCI. As such, the network impact score may contribute to a more precise and individualized cognitive prognostication in patients with ischemic stroke. Future studies should address if multimodal prediction models, combining the network impact score with de-mographics, clinical characteristics and other advanced brain imaging biomarkers, will provide accurate indi-vidualized prediction of PSCI. A tool for calculating the network impact score is freely available at https ://metavcimap.org/features/software-tools/lsm-viewer/.

Mots clés: Brain connectomics; Dementia; Diffusion-weighted imaging; Ischaemic stroke; Post-stroke cognitive impairment

Domaines: Médecine humaine et pathologie

J. Matthijs Biesbroek, Nick A. Weaver, Hugo P. Aben, Hugo J. Kuijf, Jill Abrigo, et al.. Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke. Neuroimage-Clinical, 2022, 34, ⟨10.1016/j.nicl.2022.103018⟩. ⟨hal-03703582⟩