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Article dans une revue

Isolated intraocular relapses of primary cerebral lymphomas: An loc network study

Nadia Younan 1 Carole Soussain 2, 3 Sylvain Choquet 4 Nathalie Cassoux 5 Valérie Touitou 6, 7 Anna Schmitt Olivier Chinot 8, 9 Lucie Oberic 10 Gandhi Damaj 11 Roch Houot 12, 13 Hervé Ghesquières 14 Kamel Laribi 15 Guido Ahle 16 Luc Taillandier 17, 18 Jérôme Paillassa 19 Emmanuel Gyan 20, 21 Fabrice Jardin 22, 23 Vincent Delwail 24 Jean-Pierre Marolleau 25, 26 Adrian Tempescul 27 Philippe Agapé 28 Marie Bourniquel Fabienne Vacheret 29 Ibrahim Jdid Magali Le Garff-Tavernier 4 Denis Malaise 30, 31 Agusti Alentorn 32, 1 Khê Hoang Xuan Caroline Houillier 32 
Abstract : Most relapses of primary central nervous system lymphoma (PCNSL) occur in the brain and are associated with a poor prognosis. Isolated intraocular relapses (IIORs) are rare and poorly described. We retrospectively selected from the French LOC database PCNSL patients who initially presented with cerebral localization and who experienced IIOR during the course of the disease. Of the 1472 patients included in the database, 55 patients presented an IIOR. Their median age was 68 years, and median Karnofsky Performance Status 80. IL-10 levels in the aqueous humor and/or in the vitreous were increased in 42/46 patients. 45/55 patients received systemic chemotherapy, and 11/55 received high-dose chemotherapy with autologous stem cell transplantation (HCT-ASCT) as consolidation treatment. After a median follow-up of 69 months, 42/55 patients had relapsed, including 90% of the patients who did not receive HCT-ASCT at IIOR and 40% of the patients who received HCT-ASCT at IIOR (p<0.001). The first relapse after the initial IIOR was exclusively in the eye in 23/42 patients, and 29/42 patients had a subsequent brain relapse during the course of the disease. The median progression-free survival, brain-free survival and overall survival from IIOR were 12.2, 48.6 and 57.1 months, respectively. IIOR is not exceptional in the course of PCNSL and deserves systematic ophthalmological follow-up. Its prognosis is much better than the prognosis of brain relapse, with an evolution close to that of primary vitreoretinal lymphoma. With the exception of patients who received HCT-ASCT at IIOR, almost all patients subsequently relapsed, often with other IIORs. This article is protected by copyright. All rights reserved.
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Soumis le : jeudi 7 juillet 2022 - 15:08:41
Dernière modification le : vendredi 5 août 2022 - 11:26:18



Nadia Younan, Carole Soussain, Sylvain Choquet, Nathalie Cassoux, Valérie Touitou, et al.. Isolated intraocular relapses of primary cerebral lymphomas: An loc network study. Hematological Oncology, Wiley, In press, Accepted article. ⟨10.1002/hon.3044⟩. ⟨hal-03716518⟩



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