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Plasma Amyloid Beta Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment: The BALTAZAR Study

Olivier Hanon 1 Jean-Sébastien Vidal 2, 3 Sylvain Lehmann 4, 5 Stéphanie Bombois 6, 7 Bernadette Allinquant 8 Christiane Baret-Rose Jean-Marc Tréluyer 9, 10, 11, 12 Hendy Abdoul 13 Patrick Gelé Christine Delmaire 14 Frédéric Blanc Jean-François Mangin 15 Luc Buée 16, 17, 18, 19 Jacques Touchon 20 Jacques Hugon 21, 22 Bruno Vellas 23, 24, 25 Evelyne Galbrun 26 Athanase Benetos 27, 28 Gilles Berrut 29 Elena Paillaud 30, 31 David Wallon 32 Giovanni Castelnovo 33 Lisette Volpe-Gillot 34 Marc Paccalin 35, 36, 37 Philippe Robert Olivier Godefroy 38, 39 Vincent Camus 32, 40 Joël Belmin 41 Pierre Vandel 42 Jean-Luc Novella 43 Emmanuelle Duron 44, 45 Anne-Sophie Rigaud 2, 46 Susanna Schraen-Maschke 16 Audrey Gabelle 47 
Abstract : INTRODUCTION: Blood-based biomarkers are the next challenge for Alzheimer's disease (AD) diagnosis and prognosis. METHODS: Mild cognitive impairment (MCI) participants (N = 485) of the BALTAZAR study, a large-scale longitudinal multicenter cohort, were followed-up for 3 years. A total of 165 of them converted to dementia (95% AD). Associations of conversion and plasma amyloid beta (Aβ)1-42 , Aβ1-40 , Aβ1-42 /Aβ1-40 ratio were analyzed with logistic and Cox models. RESULTS: Converters to dementia had lower level of plasma Aβ1-42 (37.1 pg/mL [12.5] vs. 39.2 [11.1] , P value = .03) and lower Aβ1-42 /Aβ1-40 ratio than non-converters (0.148 [0.125] vs. 0.154 [0.076], P value = .02). MCI participants in the highest quartile of Aβ1-42 /Aβ1-40 ratio (>0.169) had a significant lower risk of conversion (hazard ratio adjusted for age, sex, education, apolipoprotein E \epsilon4, hippocampus atrophy = 0.52 (95% confidence interval [0.31-0.86], P value = .01). DISCUSSION: In this large cohort of MCI subjects we identified a threshold for plasma Aβ1-42 /Aβ1-40 ratio that may detect patients with a low risk of conversion to dementia within 3 years.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03719721
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Soumis le : lundi 11 juillet 2022 - 14:33:55
Dernière modification le : mardi 9 août 2022 - 03:46:09

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Olivier Hanon, Jean-Sébastien Vidal, Sylvain Lehmann, Stéphanie Bombois, Bernadette Allinquant, et al.. Plasma Amyloid Beta Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment: The BALTAZAR Study. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, ⟨10.1002/alz.12613⟩. ⟨hal-03719721⟩

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