In Individuals With Subjective Cognitive Decline, Age, Memory and Speed Scores at Baseline Predict Progression to Cognitive Impairment.

Alexandre Perron (1) , Martine Roussel (2) , Sandrine Wannepain-Despretz , Mélanie Barbay (1, 2, 3) , Agnès Devendeville , Olivier Godefroy (2, 3) , Daniela Andriuta (4, 2)

1 UPJV - Université de Picardie Jules Verne
2 LNFP - Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559
3 CHU Amiens-Picardie
4 Service de neurologie [Amiens]

Some patients with subjective cognitive decline (SCD) progress to neurocognitive disorders (NCD), whereas others remain stable; however, the neuropsychological determinants of this progression have not been identified. Our objective was to examine baseline neuropsychological indicators that could discriminate between stable SCD Versus progression toward an NCD. We retrospectively included patients consulting for SCD at a university medical center's memory center (Amiens, France) who had undergone 3 or more neuropsychological assessments. Among the 80 patients with SCD, 11 had progressed to an NCD. The combination of age, memory, and speed scores at the baseline assessment predicted the progression of SCD with a sensitivity of 91%, and a negative predictive value of 98%. The present results constitute a first step (pending prospective studies) toward helping physicians to identify cases of SCD at risk of progression and, in particular, identifying patients with SCD who will not progress by examining baseline neuropsychological indicators. ClinicalTrials.gov ID: NCT04880252.

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie

Alexandre Perron, Martine Roussel, Sandrine Wannepain-Despretz, Mélanie Barbay, Agnès Devendeville, et al.. In Individuals With Subjective Cognitive Decline, Age, Memory and Speed Scores at Baseline Predict Progression to Cognitive Impairment.. Alzheimer Disease and Associated Disorders, 2022, ⟨10.1097/WAD.0000000000000520⟩. ⟨hal-03740514⟩