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Epidemiology of Infection by Pulmonary Non-Tuberculous Mycobacteria in French Guiana 2008-2018.

Abstract : INTRODUCTION: Unlike diseases caused by Mycobacterium tuberculosis, M. leprae and M. ulcerans, the epidemiology of pulmonary non-tuberculous mycobacteria (PNTM) has not received due attention in French Guiana. The main objective of the current study was to define the incidence of these PNTM infections: NTM pulmonary diseases (NTM-PD) and casual PNTM isolation (responsible of latent infection or simple colonization). The secondary objectives were to determine species diversity and geographic distribution of these atypical mycobacteria. METHODS: A retrospective observational study (2008-2018) of French Guiana patients with at least one PNTM positive respiratory sample in culture was conducted. Patients were then classified into two groups: casual PNTM isolation or pulmonary disease (NTM-PD), according to clinical, radiological and microbiological criteria defined by the American Thoracic Society / Infectious Disease Society of America (ATS / IDSA) in 2007. RESULTS: 178 patients were included, out of which 147 had casual PNTM isolation and 31 had NTM-PD. Estimated annual incidence rate of respiratory isolates was 6.17 / 100,000 inhabitants per year while that of NTM-PD was 1.07 / 100,000 inhabitants per year. Among the 178 patients, M. avium complex (MAC) was the most frequently isolated pathogen (38%), followed by M. fortuitum then M. abscessus (19% and 6% of cases respectively), the latter two mycobacteria being mainly found in the coastal center region. Concerning NTM-PD, two species were mainly involved: MAC (81%) and M. abscessus (16%). DISCUSSION/CONCLUSION: This is the first study on the epidemiology of PNTM infections in French Guiana. PNTM's incidence looks similar to other contries and metropolitan France and NTM-PD is mostly due to MAC and M.abscessus. Although French Guiana is the French territory with the highest tuberculosis incidence, NTM should not be overlooked.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03779209
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Soumis le : vendredi 16 septembre 2022 - 15:04:06
Dernière modification le : samedi 17 septembre 2022 - 03:47:45

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Milène Chaptal, Claire Andrejak, Timothée Bonifay, Emmanuel Beillard, Geneviève Guillot, et al.. Epidemiology of Infection by Pulmonary Non-Tuberculous Mycobacteria in French Guiana 2008-2018.. PLoS Neglected Tropical Diseases, Public Library of Science, 2022, 16 (9), pp.e0010693. ⟨10.1371/journal.pntd.0010693⟩. ⟨hal-03779209⟩

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