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Early Improvement of Neuropsychological Impairments During Detoxification in Patients with Alcohol Use Disorder.

Abstract : AIMS: To assess recovery of alcohol-related neuropsychological deficits in a group of patients with pure severe alcohol use disorder (AUD) during a detoxification program using the Brief Evaluation of Alcohol-Related Neuropsychological Impairment (BEARNI) test. METHODS: Thirty-two patients with severe AUD using DSM-IV criteria (24 men, mean age\,=\,45.5\,±\,6.8~years old) were assessed using the BEARNI 8\,±\,2~days after alcohol cessation (T1) and then were reassessed within 18\,±\,2~days after alcohol cessation (T2). The primary study endpoint was the number of patients initially impaired at T1 who recovered cognitive functions at T2 assessment. RESULTS: At T1, 59% (n\,=\,19) patients with pure severe AUD had at least one impaired cognitive function assessed by the BEARNI. At T2, 63% of the patients with AUD with deficits at T1 had normal BEARNI cognitive scores (χ2\,=\,7.7, P\,=\,0.005); specifically, the percentages of participants with normal subtest scores were 63% on memory (χ2\,=\,12.4, P\,=\,0.0004), 100% on verbal fluency (χ2\,=\,16; P\,=\,<0.0001), 60% on alphabetical span (χ2\,=\,12.8; P\,=\,0.0003) and 67% on visuospatial (χ2\,=\,15, P\,=\,0.0001). CONCLUSIONS: The cognitive impairments of two-thirds of patients with pure AUD included in the present study recovered within 18~days of abstinence, earlier than reported in previous studies.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03814208
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Soumis le : jeudi 13 octobre 2022 - 18:05:47
Dernière modification le : vendredi 14 octobre 2022 - 03:10:32

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Bernard Angerville, Ludivine Ritz, Anne-Lise Pitel, Hélène Beaunieux, Hakim Houchi, et al.. Early Improvement of Neuropsychological Impairments During Detoxification in Patients with Alcohol Use Disorder.. Alcohol and Alcoholism, 2022, pp.agac048. ⟨10.1093/alcalc/agac048⟩. ⟨hal-03814208⟩

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