Early Improvement of Neuropsychological Impairments During Detoxification in Patients with Alcohol Use Disorder. - Université de Picardie Jules Verne Accéder directement au contenu
Article Dans Une Revue Alcohol and Alcoholism Année : 2022

Early Improvement of Neuropsychological Impairments During Detoxification in Patients with Alcohol Use Disorder.

Résumé

AIMS: To assess recovery of alcohol-related neuropsychological deficits in a group of patients with pure severe alcohol use disorder (AUD) during a detoxification program using the Brief Evaluation of Alcohol-Related Neuropsychological Impairment (BEARNI) test. METHODS: Thirty-two patients with severe AUD using DSM-IV criteria (24 men, mean age\,=\,45.5\,±\,6.8~years old) were assessed using the BEARNI 8\,±\,2~days after alcohol cessation (T1) and then were reassessed within 18\,±\,2~days after alcohol cessation (T2). The primary study endpoint was the number of patients initially impaired at T1 who recovered cognitive functions at T2 assessment. RESULTS: At T1, 59% (n\,=\,19) patients with pure severe AUD had at least one impaired cognitive function assessed by the BEARNI. At T2, 63% of the patients with AUD with deficits at T1 had normal BEARNI cognitive scores (χ2\,=\,7.7, P\,=\,0.005); specifically, the percentages of participants with normal subtest scores were 63% on memory (χ2\,=\,12.4, P\,=\,0.0004), 100% on verbal fluency (χ2\,=\,16; P\,=\,<0.0001), 60% on alphabetical span (χ2\,=\,12.8; P\,=\,0.0003) and 67% on visuospatial (χ2\,=\,15, P\,=\,0.0001). CONCLUSIONS: The cognitive impairments of two-thirds of patients with pure AUD included in the present study recovered within 18~days of abstinence, earlier than reported in previous studies.
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Dates et versions

hal-03814208 , version 1 (13-10-2022)

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Bernard Angerville, Ludivine Ritz, Anne Lise Pitel, Hélène Beaunieux, Hakim Houchi, et al.. Early Improvement of Neuropsychological Impairments During Detoxification in Patients with Alcohol Use Disorder.. Alcohol and Alcoholism, 2022, pp.agac048. ⟨10.1093/alcalc/agac048⟩. ⟨hal-03814208⟩
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