Health-related quality of life in older patients surviving ICU treatment for COVID-19: results from an international observational study of patients older than 70 years

Ivo Soliman , Susannah Leaver , Hans Flaatten , Jesper Fjølner , Bernhard Wernly , Raphael Bruno , Antonio Artigas , Bernardo Bollen Pinto , Joerg Schefold , Michael Beil , Sigal Sviri , Peter Vernon van Heerden , Wojciech Szczeklik , Muhammed Elhadi , Michael Joannidis , Sandra Oeyen , Tilemachos Zafeiridis , Jakob Wollborn , Maria Jose Arche Banzo , Kristina Fuest , Brian Marsh , Finn Andersen , Rui Moreno , Ariane Boumendil (1, 2) , Bertrand Guidet (1, 2) , Christian Jung , Dylan de Lange , Philipp Eller , Michael Joannidis , Dieter Mesotten , Pascal Reper , Sandra Oeyen , Walter Swinnen , Helene Brix , Jens Brushoej , Maja Villefrance , Helene Korvenius Nedergaard , Anders Thais Bjerregaard , Ida Riise Balleby , Kasper Andersen , Maria Aagaard Hansen , Stine Uhrenholt , Helle Bundgaard , Jesper Fjølner , Aliae Ar Hussein Mohamed , Rehab Salah , Yasmin Khairy Nasreldin Mohamed Ali , Kyrillos Wassim , Yumna Elgazzar , Samar Tharwat , Ahmed Azzam , Ayman Abdelmawgoad Habib , Hazem Maarouf Abosheaishaa , Mohammed Azab , Susannah Leaver , Arnaud Galbois , Bertrand Guidet , Cyril Charron , Emmanuel Guerot , Guillaume Besch , Jean-Philippe Rigaud , Julien Maizel (3) , Michel Djibré , Philippe Burtin , Pierre Garcon , Saad Nseir , Xavier Valette , Nica Alexandru , Nathalie Marin , Marie Vaissiere , Gaëtan Plantefeve , Thierry Vanderlinden , Igor Jurcisin , Bruno Megarbane (4) , Anais Caillard , Arnaud Valent , Marc Garnier , Sebastien Besset , Johanna Oziel , Jean-Herlé Raphaelen , Stéphane Dauger , Guillaume Dumas , Bruno Goncalves , Gaël Piton , Christian Jung , Raphael Romano Bruno , Malte Kelm , Georg Wolff , Eberhard Barth , Ulrich Goebel , Eberhard Barth , Anselm Kunstein , Michael Schuster , Martin Welte , Matthias Lutz , Patrick Meybohm , Stephan Steiner , Tudor Poerner , Hendrik Haake , Stefan Schaller , Detlef Kindgen-Milles , Christian Meyer , Muhammed Kurt , Karl Friedrich Kuhn , Winfried Randerath , Jakob Wollborn , Zouhir Dindane , Hans-Joachim Kabitz , Ingo Voigt , Gonxhe Shala , Andreas Faltlhauser , Nikoletta Rovina , Zoi Aidoni , Evangelia Chrisanthopoulou , Antonios Papadogoulas , Mohan Gurjar , Ata Mahmoodpoor , Abdullah Khudhur Ahmed , Brian Marsh , Ahmed Elsaka , Sigal Sviri , Vittoria Comellini , Ahmed Rabha , Hazem Ahmed , Silvio Namendys-Silva , Abdelilah Ghannam , Martijn Groenendijk , Marieke Zegers , Dylan de Lange , Alex Cornet , Mirjam Evers , Lenneke Haas , Tom Dormans , Willem Dieperink , Luis Romundstad , Britt Sjøbø , Finn Andersen , Hans Frank Strietzel , Theresa Olasveengen , Michael Hahn , Miroslaw Czuczwar , Ryszard Gawda , Jakub Klimkiewicz , Maria Campos de Lurdessantos , André Gordinho , Henrique Santos , Rui Assis , Ana Isabel Pinho Oliveira , Mohamed Raafat Badawy , David Perez-Torres , Gemma Gomà , Mercedes Ibarz Villamayor , Angela Prado Mira , Patricia Jimeno Cubero , Susana Arias Rivera , Teresa Tomasa , David Iglesias , Eric Mayor Vázquez , Cesar Aldecoa , Aida Fernández Ferreira , Begoña Zalba-Etayo , Isabel Canas-Perez , Luis Tamayo-Lomas , Cristina Diaz-Rodriguez , Susana Sancho , Jesús Priego , Enas Abualqumboz , Momin Majed Yousuf Hilles , Mahmoud Saleh , Nawfel Ben-Hamouda , Andrea Roberti , Alexander Dullenkopf , Yvan Fleury , Bernardo Bollen Pinto , Joerg Schefold , Mohammed Al-Sadawi , Nicolas Serck , Elisabeth Dewaele , Pritpal Kumar , Camilla Bundesen , Richard Innes , James Gooch , Lenka Cagova , Elizabeth Potter , Michael Reay , Miriam Davey , Sally Humphreys , Caroline Hauw Berlemont , Benjamin Glenn Chousterman , François Dépret , Alexis Ferre , Lucie Vettoretti , Didier Thevenin , Andreas Faltlhauser , Milena Milovanovic , Philipp Simon , Marco Lorenz , Sandra Emily Stoll , Simon Dubler , Kristina Fuest , Francesk Mulita , Eumorifa Kondili , Ioannis Andrianopoulos , Iwan Meynaar , Alexander Daniel Cornet , Britt Sjøbøe , Anna Kluzik , Paweł Zatorski , Tomasz Drygalski , Wojciech Szczeklik , Joanna Solek-Pastuszka , Dariusz Onichimowski , Jan Stefaniak , Karina Stefanska-Wronka , Ewa Zabul , Filipe Sousa Cardoso , Maria José Arche Banzo , Teresa Maria Tomasa-Irriguible , Ángela Prado Mira , Susana Arias-Rivera , Fernando Frutos-Vivar , Sonia Lopez-Cuenca , Pablo Ruiz de Gopegui , Nour Abidi , Ivan Chau , Richard Pugh , Sara Smuts

1 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
2 CHU Saint-Antoine [AP-HP]
3 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517
4 OPTeN (UMR_S 1144 / U1144) - Optimisation thérapeutique en Neuropsychopharmacologie

Background health-related quality of life (HRQoL) is an important patient-centred outcome in patients surviving ICU admission for COVID-19. It is currently not clear which domains of the HRQoL are most affected. Objective to quantify HRQoL in order to identify areas of interventions. Design prospective observation study. Setting admissions to European ICUs between March 2020 and February 2021. Subjects patients aged 70 years or older admitted with COVID-19 disease. Methods collected determinants include SOFA-score, Clinical Frailty Scale (CFS), number and timing of ICU procedures and limitation of care, Katz Activities of Daily Living (ADL) dependence score. HRQoL was assessed at 3 months after ICU admission with the Euro-QoL-5D-5L questionnaire. An outcome of ≥4 on any of Euro-QoL-5D-5L domains was considered unfavourable. Results in total 3,140 patients from 14 European countries were included in this study. Three months after inclusion, 1,224 patients (39.0%) were alive and the EQ-5D-5L from was obtained. The CFS was associated with an increased odds ratio for an unfavourable HRQoL outcome after 3 months; OR 1.15 (95% confidence interval (CI): 0.71–1.87) for CFS 2 to OR 4.33 (95% CI: 1.57–11.9) for CFS ≧ 7. The Katz ADL was not statistically significantly associated with HRQoL after 3 months. Conclusions in critically ill old intensive care patients suffering from COVID-19, the CFS is associated with the subjectively perceived quality of life. The CFS on admission can be used to inform patients and relatives on the risk of an unfavourable qualitative outcome if such patients survive.

Mots clés: COVID-19; Intensive Care Unit (ICU); Older people; Quality of Life; Survival; frailty; COVID-19

Domaines: Sciences du Vivant [q-bio]

Ivo Soliman, Susannah Leaver, Hans Flaatten, Jesper Fjølner, Bernhard Wernly, et al.. Health-related quality of life in older patients surviving ICU treatment for COVID-19: results from an international observational study of patients older than 70 years. Age and Ageing, 2022, 51 (2), pp.afab278. ⟨10.1093/ageing/afab278⟩. ⟨hal-03820612⟩