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A New Partially Hydrolyzed Whey-Based Follow-on Formula with Age-Adapted Protein Content Supports Healthy Growth during the First Year of Life.

Abstract : BACKGROUND: Standard infant formulae often have higher protein content than breastmilk in order to compensate for potentially lower digestibility; excess protein intake may promote adverse effects later in life. A new partially hydrolyzed whey-based (pHF-W) follow-on formula (FoF) with age-adapted protein content was evaluated for growth and gastrointestinal (GI) tolerance in healthy infants. METHODS: Formula-fed (FF) infants (n = 108) received standard pHF-W formula (1.9 g protein/100 kcal) from enrollment (age ≤q 30 days) until age 120 days followed by new pHF-W FoF (1.6 g protein/100 kcal) until 360 days. Weight gain velocity (WGV) (mean daily WG from enrollment to age 180 days) was compared to WHO growth standards and a breastfed (BF) reference group (n = 86) (non-inferiority margin -3 g/day). GI tolerance was assessed using a validated questionnaire (scale range 13-65). RESULTS: WGV in FF infants (mean ± SD 24.0 ± 4.4 g/day) was non-inferior to BF (23.7 ± 3.9 g/day) and WHO standards (all p ≤q 0.013). Weight-for-age, length-for-age, weight-for-length, and head circumference-for-age z-scores of FF infants were not significantly different from BF at any timepoint. Symptoms of GI intolerance were low (≤q23) at all timepoints and similar between groups. CONCLUSION: A new pHF-W FoF with age-adapted protein content fed sequentially after standard pHF-W infant formula is safe, well-tolerated, and promotes a healthy growth pattern consistent with BF infants and WHO standards during the first year of life. CLINICAL TRIAL REGISTRATION: [https://clinicaltrials.gov/], identifier [NCT03276663].
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https://hal-u-picardie.archives-ouvertes.fr/hal-03823324
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Soumis le : jeudi 20 octobre 2022 - 18:41:10
Dernière modification le : mardi 29 novembre 2022 - 10:12:03

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Distributed under a Creative Commons Paternité 4.0 International License

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Claude Billeaud, Latif Adamon, Hugues Piloquet, Nicholas P Hays, Lénaïck Dupuis, et al.. A New Partially Hydrolyzed Whey-Based Follow-on Formula with Age-Adapted Protein Content Supports Healthy Growth during the First Year of Life.. Frontiers in Pediatrics, 2022, 10, pp.1-16. ⟨10.3389/fped.2022.937882⟩. ⟨hal-03823324⟩

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