Preparation of nucleoside derivative carrying an isothiazole or oxathiole cycle with an antiproliferative activity

Denis Postel (1) , Jean-Pierre Marolleau (2, 3) , Solen Josse (1) , Albert Nguyen van Nhien (1)

1 LG2A - Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources - UMR CNRS 7378
2 Laboratoire d'Hématologie [CHU Amiens]
3 HEMATIM - HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666

The invention relates to novel molecules pertaining to the family of nucleoside analogues, with an antiproliferative activity. The invention also relates to the method for the synthesis of said molecules and to the application thereof in the treatment of cancer.

Domaines: Chimie

Denis Postel, Jean-Pierre Marolleau, Solen Josse, Albert Nguyen van Nhien. Preparation of nucleoside derivative carrying an isothiazole or oxathiole cycle with an antiproliferative activity. France, Patent n° : WO2018109416A1. 2018, https://patents.google.com/patent/WO2018109416A1/en?oq=WO2018109416A1. ⟨hal-03834010⟩