Circulating Lipoprotein-associated Phospholipase A2 in High-grade Carotid Stenosis: A New Biomarker for Predicting Unstable Plaque - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Vascular and Endovascular Surgery Année : 2012

Circulating Lipoprotein-associated Phospholipase A2 in High-grade Carotid Stenosis: A New Biomarker for Predicting Unstable Plaque

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1
G. Sarlon-Bartoli
  • Fonction : Auteur
A. Boudes
  • Fonction : Auteur
C. Buffat
  • Fonction : Auteur
M.A. Bartoli
  • Fonction : Auteur
M.D. Piercecchi-Marti
  • Fonction : Auteur
E. Sarlon
  • Fonction : Auteur
L. Arnaud
  • Fonction : Auteur
B. Thevenin
  • Fonction : Auteur
C. Squarcioni
  • Fonction : Auteur
F. Nicoli
  • Fonction : Auteur
F. Dignat-George
  • Fonction : Auteur
F. Sabatier
  • Fonction : Auteur
P.E. Magnan
  • Fonction : Auteur

Résumé

Objective: To test plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) in patients with high-grade carotid stenosis according to plaque histology. Methods: This cross-sectional single-centre study included patients with ≥70% North American Symptomatic Carotid Endarterectomy Trial (NASCET) carotid stenosis, who were treated surgically. Serum Lp-PLA2 and high-sensitivity C-reactive protein (hs-CRP) were determined on the day of surgery. Histopathological analysis classified carotid plaque as stable or unstable, according to AHA classification. Results: Of the 42 patients (mean age 70.4 ± 10.5 years; 67% men), neurological symptoms were present in 16 (38%). Unstable plaques were found in 23 (55%). Median plasma level of Lp-PLA2 was significantly higher in patients with unstable plaque compared to those with stable plaque (222.4 (174.9-437.5) interquartile range (IQR) 63.5 vs. 211.1 (174.9-270.6) IQR 37.2 ng ml(-1); p = 0.02). Moreover, median Lp-PLA2 level were higher in asymptomatic patients with unstable plaque (226.8 ng ml(-1) (174.9-437.5) IQR 76.8) vs. stable plaque (206.9 ng ml(-1) (174.9-270.6) IQR 33.7; p = 0.16). Logistic regression showed that only the neurological symptoms (OR = 30.9 (3.7-244.6); p < 0.001) and the plasma Lp-PLA2 level (OR = 1.7 (1.1-12.3); p = 0.03) were independently associated with unstable carotid plaque as defined by histology. Conclusions: This study showed that circulating Lp-PLA2 was increased in patients with high-grade carotid stenosis and unstable plaque. Lp-PLA2 may be a relevant biomarker to guide for invasive therapy in asymptomatic patients with carotid artery disease.

Dates et versions

hal-03891820 , version 1 (09-12-2022)

Identifiants

Citer

G. Sarlon-Bartoli, A. Boudes, C. Buffat, M.A. Bartoli, M.D. Piercecchi-Marti, et al.. Circulating Lipoprotein-associated Phospholipase A2 in High-grade Carotid Stenosis: A New Biomarker for Predicting Unstable Plaque. European Journal of Vascular and Endovascular Surgery, 2012, 43 (2), pp.154-159. ⟨10.1016/j.ejvs.2011.10.009⟩. ⟨hal-03891820⟩

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