Prevalence and determinants of fatigue in patients with IBD: a cross-sectional survey from the GETAID.

Aurelien Amiot (1) , Sayma Chaibi (2) , Yoram Bouhnik (3) , Melanie Serrero (4) , Jerome Filippi (5) , Xavier Roblin (6) , Anne Bourrier (7) , Guillaume Bouguen (8, 9, 10) , Denis Franchimont (11) , Guillaume Savoye (12, 13, 14, 15) , Anthony Buisson (16, 17) , Edouard Louis (18) , Stephane Nancey (19) , Vered Abitbol (20) , Jean-Marie Reimund (21) , Olivier Dewit (22) , Lucine Vuitton (23) , Nicolas Mathieu (24) , Laurent Peyrin-Biroulet (25, 26) , Cyrielle Gilletta (27) , Matthieu Allez (28) , Stephanie Viennot (29) , Catherine Le Berre (30, 31) , Nina Dib (32) , Hedia Brixi , Claire Painchart , Laurianne Plastaras , Romain Altwegg (33) , Mathurin Fumery (34, 35) , Ludovic Caillo (36) , David Laharie (37) , Maria Nachury (38)

1 AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)
2 Hôpital Henri Mondor
3 Hôpital Beaujon [AP-HP]
4 Hôpital Nord [CHU - APHM]
5 Immunité muqueuse et vaccination
6 Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne]
7 CRSA - Centre de Recherche Saint-Antoine
8 NuMeCan - Nutrition, Métabolismes et Cancer
9 CHU Pontchaillou [Rennes]
10 CIC - Centre d'Investigation Clinique [Rennes]
11 ULB - Hôpital Erasme [Bruxelles]
12 ADEN - Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau
13 IRIB - Institute for Research and Innovation in Biomedicine
14 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
15 Service d'Hépato-Gastroentérologie [CHU Rouen]
16 CHU Clermont-Ferrand
17 M2iSH - Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte
18 CHU-Liège - Centre Hospitalier Universitaire de Liège
19 HCL - Hospices Civils de Lyon
20 Service de Gastro-entérologie [CHU Cochin]
21 Voies de Signalisation du Développement et du Stress Cellulaire dans les Cancers Digestifs et Urologiques
22 KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven
23 Service de Gastro-Entérologie [CHRU Besançon]
24 CHU Grenoble
25 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
26 Service d'Hépato-gastro-entérologie [CHRU Nancy]
27 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
28 AP-HP - Hopital Saint-Louis [AP-HP]
29 CHU Caen
30 Institut des Maladies de l'Appareil Digestif
31 CIC Nantes - Centre d’Investigation Clinique de Nantes
32 CHU Angers - Centre Hospitalier Universitaire d'Angers
33 CHU Montpellier
34 CHU Amiens-Picardie
35 PERITOX - Périnatalité et Risques Toxiques - UMR INERIS_I 1
36 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
37 CHU Bordeaux [Bordeaux]
38 INFINITE (Ex-Liric) - Institute for Translational Research in Inflammation - U 1286

Background: Fatigue is commonly reported by patients with inflammatory bowel disease (IBD), but the determinants of IBD-related fatigue have yet to be determined. Aims: To identify the factors associated with fatigue in a large population of patients with IBD. Patients and methods: Fatigue and nine other IBD-related disability dimensions were assessed in a cohort of 1704 consecutive patients with IBD using the IBD-disk questionnaire in a cross-sectional survey of 42 French and Belgian centers. Fatigue and severe fatigue were defined as energy subscores >5 and >7, respectively. Determinants of fatigue were assessed using univariate and multivariate analyses (odds ratios (ORs) are provided with 95% confidence intervals). Results: The prevalence rates of fatigue and severe fatigue were 54.1% and 37.1%, respectively. Both fatigue and severe fatigue were significantly higher in patients with active disease than in patients with inactive disease (64.9% vs. 44.7% and 47.4% vs. 28.6%, respectively; p<0.001 for both comparisons). In the multivariate analysis stratified by age, sex, type of IBD and IBD activity, fatigue was associated with age >40 years (OR=0.71 [0.54-0.93]), female sex (OR=1.48 [1.13-1.93]), IBD-related sick leave (OR=1.61 (1.19-2.16]), and joint pain (OR=1.60 [1.17-2.18]), abdominal pain (OR=1.78 [1.29-2.45]), regulating defecation (OR=1.67 [1.20-2.32]), education and work (OR=1.96 [1.40-2.75]), body image (OR=1.38 [1.02-1.86]), sleep (OR=3.60 [2.66-4.88]) and emotions (OR=3.60 [2.66-4.88]) subscores > 5. Conclusion: Determinants of fatigue are not restricted to IBD-related factors but also include social factors, sleep, and emotional disturbances, thus supporting a holistic approach to IBD patient care.

Mots clés: Crohn’s disease; disability; fatigue; inflammatory bowel disease; ulcerative colitis

Domaines: Médecine humaine et pathologie

Aurelien Amiot, Sayma Chaibi, Yoram Bouhnik, Melanie Serrero, Jerome Filippi, et al.. Prevalence and determinants of fatigue in patients with IBD: a cross-sectional survey from the GETAID.. Journal of Crohn's & Colitis, 2023, pp.jjad060. ⟨10.1093/ecco-jcc/jjad060⟩. ⟨hal-04052487⟩