Prevalence and determinants of fatigue in patients with IBD: a cross-sectional survey from the GETAID.

Aurelien Amiot (1, 2) , Sayma Chaibi (3) , Yoram Bouhnik (4) , Melanie Serrero (5) , Jerome Filippi (6, 7) , Xavier Roblin (8) , Anne Bourrier (9) , Guillaume Bouguen (10, 11, 12) , Denis Franchimont (13) , Guillaume Savoye (14, 15, 16, 17) , Anthony Buisson (18, 19) , Edouard Louis (20) , Stephane Nancey (21, 22) , Vered Abitbol (23) , Jean-Marie Reimund (24, 25) , Olivier Dewit (26, 27) , Lucine Vuitton (28) , Nicolas Mathieu (29) , Laurent Peyrin-Biroulet (30, 31) , Cyrielle Gilletta (32) , Matthieu Allez (33) , Stephanie Viennot (34) , Catherine Le Berre (35, 36) , Nina Dib (37) , Hedia Brixi (38) , Claire Painchart (39) , Laurianne Plastaras (40) , Romain Altwegg (41) , Mathurin Fumery (42, 43) , Ludovic Caillo (44) , David Laharie (45) , Maria Nachury (46)

1 Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
2 CESP - Centre de recherche en épidémiologie et santé des populations
3 Hôpital Henri Mondor
4 Hôpital Beaujon [AP-HP]
5 Hôpital Nord [CHU - APHM]
6 Immunité muqueuse et vaccination
7 CHU Nice - Centre Hospitalier Universitaire de Nice
8 Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne]
9 CRSA - Centre de Recherche Saint-Antoine
10 NuMeCan - Nutrition, Métabolismes et Cancer
11 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
12 CIC - Centre d'Investigation Clinique [Rennes]
13 ULB - Hôpital Erasme [Bruxelles]
14 ADEN - Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau
15 IRIB - Institute for Research and Innovation in Biomedicine
16 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
17 Service d'Hépato-Gastroentérologie [CHU Rouen]
18 CHU Clermont-Ferrand
19 M2iSH - Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte
20 CHU-Liège - Centre Hospitalier Universitaire de Liège
21 HCL - Hospices Civils de Lyon
22 CIRI - Centre International de Recherche en Infectiologie
23 Service de Gastro-entérologie [CHU Cochin]
24 Voies de Signalisation du Développement et du Stress Cellulaire dans les Cancers Digestifs et Urologiques
25 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
26 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
27 Cliniques Universitaires Saint-Luc [Bruxelles]
28 Service de Gastro-Entérologie [CHRU Besançon]
29 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
30 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
31 Service d'Hépato-gastro-entérologie [CHRU Nancy]
32 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
33 AP-HP - Hopital Saint-Louis [AP-HP]
34 CHU Caen
35 Institut des Maladies de l'Appareil Digestif
36 CIC Nantes - Centre d’Investigation Clinique de Nantes
37 CHU Angers - Centre Hospitalier Universitaire d'Angers
38 Hôpital universitaire Robert Debré [Reims]
39 Centre hospitalier [Valenciennes, Nord]
40 Hôpital pasteur [Colmar]
41 CHU Montpellier
42 CHU Amiens-Picardie
43 PERITOX - Périnatalité et Risques Toxiques - UMR INERIS_I 1
44 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
45 CHU Bordeaux
46 INFINITE (Ex-Liric) - Institute for Translational Research in Inflammation - U 1286

Background: Fatigue is commonly reported by patients with inflammatory bowel disease (IBD), but the determinants of IBD-related fatigue have yet to be determined.Aims: To identify the factors associated with fatigue in a large population of patients with IBD.Patients and methods: Fatigue and nine other IBD-related disability dimensions were assessed in a cohort of 1704 consecutive patients with IBD using the IBD-disk questionnaire in a cross-sectional survey of 42 French and Belgian centers. Fatigue and severe fatigue were defined as energy subscores >5 and >7, respectively. Determinants of fatigue were assessed using univariate and multivariate analyses (odds ratios (ORs) are provided with 95% confidence intervals).Results: The prevalence rates of fatigue and severe fatigue were 54.1% and 37.1%, respectively. Both fatigue and severe fatigue were significantly higher in patients with active disease than in patients with inactive disease (64.9% vs. 44.7% and 47.4% vs. 28.6%, respectively; p<0.001 for both comparisons). In the multivariate analysis stratified by age, sex, type of IBD and IBD activity, fatigue was associated with age >40 years (OR=0.71 [0.54-0.93]), female sex (OR=1.48 [1.13-1.93]), IBD-related sick leave (OR=1.61 (1.19-2.16]), and joint pain (OR=1.60 [1.17-2.18]), abdominal pain (OR=1.78 [1.29-2.45]), regulating defecation (OR=1.67 [1.20-2.32]), education and work (OR=1.96 [1.40-2.75]), body image (OR=1.38 [1.02-1.86]), sleep (OR=3.60 [2.66-4.88]) and emotions (OR=3.60 [2.66-4.88]) subscores > 5.Conclusion: Determinants of fatigue are not restricted to IBD-related factors but also include social factors, sleep, and emotional disturbances, thus supporting a holistic approach to IBD patient care.

Mots clés: Crohn’s disease; disability; fatigue; inflammatory bowel disease; ulcerative colitis

Domaines: Médecine humaine et pathologie

Aurelien Amiot, Sayma Chaibi, Yoram Bouhnik, Melanie Serrero, Jerome Filippi, et al.. Prevalence and determinants of fatigue in patients with IBD: a cross-sectional survey from the GETAID.. Journal of Crohn's and Colitis, 2023, 17 (9), pp.1418-1425. ⟨10.1093/ecco-jcc/jjad060⟩. ⟨hal-04052487⟩