Two-year prognosis of acute coronary syndrome during the first wave of the coronavirus disease 2019 pandemic

Paul Gabrion (1) , Christophe Beyls (1) , Nicolas Martin (1) , Genevieve Jarry (1) , Arthur Facq (1) , Alexandre Fournier (1) , Dorothée Malaquin (1) , Yazine Mahjoub (2, 3) , Hervé Dupont (1, 4) , Momar Diouf (1) , Helene Duquenne (1) , Julien Maizel (5, 3) , Yohann Bohbot (1, 3) , Laurent Leborgne (1) , Alexis Hermida (1)

1 CHU Amiens-Picardie
2 Service de dermatologie [CHU d'Amiens-Picardie]
3 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517
4 SSPC - Simplification des soins chez les patients complexes - UR UPJV 7518
5 Unité Médicale de Soins Intensifs

Background: The first wave of the coronavirus disease 2019 pandemic significantly changed behaviour in terms of access to healthcare. Aim: To assess the effects of the pandemic and initial lockdown on the incidence of acute coronary syndrome and its long-term prognosis. Methods: Patients admitted for acute coronary syndrome from 17 March to 6 July 2020 and from 17 March to 6 July 2019 were included. The number of admissions for acute coronary syndrome, acute complication rates and 2-year rates of survival free from major adverse cardiovascular events or death from any cause were compared according to the period of hospitalization. Results: In total, 289 patients were included. We observed a 30±3% drop in acute coronary syndrome admissions during the first lockdown, which did not recover in the 2months after it was lifted. At 2years, there were no significant differences in the combined endpoint of major adverse cardiovascular events or death from any cause between the different periods (P=0.34). Being hospitalized during lockdown was not predictive of adverse events during follow-up (hazard ratio 0.87, 95% confidence interval 0.45-1.66; P=0.67). Conclusions: We did not observe an increased risk of major cardiovascular events or death at 2years from initial hospitalization for patients hospitalized during the first lockdown, adopted in March 2020 in response to the coronavirus disease 2019 pandemic, potentially as a result of the lack of power of the study.

Mots clés: COVID-19; Incidence; Myocardial infarction; Pandemic; Prognosis

Domaines: Médecine humaine et pathologie

Paul Gabrion, Christophe Beyls, Nicolas Martin, Genevieve Jarry, Arthur Facq, et al.. Two-year prognosis of acute coronary syndrome during the first wave of the coronavirus disease 2019 pandemic. Archives of cardiovascular diseases, 2023, ⟨10.1016/j.acvd.2023.03.001⟩. ⟨hal-04067897⟩