N°253 – Poststroke action slowing: Motor and attentional impairments and its anatomy, evidence from lesion-symptom mapping, disconnection and fMRI activation studies - Université de Picardie Jules Verne Accéder directement au contenu
Proceedings/Recueil Des Communications Clinical Neurophysiology Année : 2023

N°253 – Poststroke action slowing: Motor and attentional impairments and its anatomy, evidence from lesion-symptom mapping, disconnection and fMRI activation studies

Elisa Ouin

Résumé

Objectives Although action slowing is the main cognitive impairment in stroke survivors, its mechanisms and determinants remain poorly known. The present study aimed to determine the mechanism of poststroke action slowing and identify its anatomy. Content Methods: Action speed in the GRECogVASC cohort was assessed using finger tapping and simple reaction time (SRT) tests performed with both hands. Imaging determinants were identified using validated mVLSM analyses and disconnection analysis, and compared with fMRI activation meta-analytic database. Results: Both the tapping time and the SRT were 10.7% slower in the 394 patients (p = 0.0001) (group x test: p = 0.2). The intra-individual distribution curve was characterized by a rightward shift with spared attentional peak. The mVLSM analyses showed that tapping was associated with frontostriatal tract lesions (p = 0.0007), SRT, with lesions in the frontostriatal tract (p = 0.04) and the orbital part of F3 (p = 0.0001) and SRT-tapping index (reflecting sustained alertness), with lesions in the orbital part of F3 (p = 0.0001). All lesions were located in the right hemisphere only and were responsible for the disconnection of several frontal structures (F3orbital, F1, premotor and cingulate regions), also observed using fMRI activation meta-analytic data Conclusion: Our results confirmed the marked impairment of action speed in stroke, showing that motor slowing constitutes its primary mechanism and is related to lesions in the right frontostriatal tract. Together with fMRI activation data, it refines the anatomy of action speed.

Dates et versions

hal-04104662 , version 1 (24-05-2023)

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Elisa Ouin, Martine Roussel, Ardalan Aarabi, Audrey Courselle, Sophie Tasseel-Ponche, et al.. N°253 – Poststroke action slowing: Motor and attentional impairments and its anatomy, evidence from lesion-symptom mapping, disconnection and fMRI activation studies. Clinical Neurophysiology, Clinical Neurophysiology, 150, pp.e153, 2023, ⟨10.1016/j.clinph.2023.03.242⟩. ⟨hal-04104662⟩
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