Comparison of effects from gamma, e-beam and X-ray radiation on multilayer polymer films used in biopharmaceutical devices by chemometric treatment of spectroscopic data

Blanche Krieguer (1, 2) , Sylvain R A Marque (2) , Samuel Dorey , Fabien Girard (3, 1) , Yelin Ni , Donghui Li , Mark K Murphy , Leonard S Fifield , Nathalie Dupuy (1)

1 IMBE - Institut méditerranéen de biodiversité et d'écologie marine et continentale
2 ICR - Institut de Chimie Radicalaire
3 AMU - Aix Marseille Université

The present study investigated the effects of gamma-ray, electron beam, and X-ray radiation on polymers in EVA/ EVOH/EVA multilayer films. Spectroscopic methods, including FTIR and UV-Vis, were employed in conjunction with chemometric treatments such as PCA, SIMPLISMA treatments, and PLS models. The feasibility of dose prediction on multilayer film, given a known dose, is attainable across various irradiation technologies. Both gamma ray and X-ray exhibit comparable effects on the multilayer film, and it is feasible to anticipate the dose released on the film by utilizing UV-Vis spectra or infrared spectra for gamma ray or X-ray of a predetermined dose.

Mots clés: FTIR UV-VIS; Chemometrics; Gamma-ray; X-ray e-beam

Domaines: Sciences de l'ingénieur [physics]

Blanche Krieguer, Sylvain R A Marque, Samuel Dorey, Fabien Girard, Yelin Ni, et al.. Comparison of effects from gamma, e-beam and X-ray radiation on multilayer polymer films used in biopharmaceutical devices by chemometric treatment of spectroscopic data. Radiation Physics and Chemistry, 2024, 218, ⟨10.1016/j.radphyschem.2024.111607⟩. ⟨hal-04470509⟩