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The hypoxic test in preterm neonates reinvestigated

Abstract : Aim: We currently lack a suitable gold-standard method for implementation on modern equipment to assess peripheral chemoreceptor sensitivity. The aim of the present study was to develop an accurate and reproducible method for assessing peripheral chemoreceptors sensitivity in sleeping preterm neonates. Methods: A poïkilocapnic hypoxic test was performed twice during rapid eye movement sleep (REM sleep) and non-rapid eye movement sleep (nonREM sleep). The infant breathed hypoxic gas (15% O 2) for 60 s. The ventilatory response to hypoxia was assessed by comparing minute ventilation during the control period (21% O 2) with successive 4-cycles sequences during hypoxia. We detected the first statistically significant increase in minute ventilation and recorded the corresponding response time.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03525948
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Soumis le : jeudi 20 octobre 2022 - 15:11:45
Dernière modification le : samedi 22 octobre 2022 - 03:06:23

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Christelle Kouakam, Erwan Stephan, André Léké, Guy Kongolo, Elodie Haraux, et al.. The hypoxic test in preterm neonates reinvestigated. Pediatric Pulmonology, 2017, 53 (4), pp.483 - 491. ⟨10.1002/ppul.23907⟩. ⟨hal-03525948⟩

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