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Article Dans Une Revue Expert Opinion on Biological Therapy Année : 2018

Corneal epithelial stem cells for corneal injury


Introduction: Ocular surface diseases with limbal insufficiency represent a therapeutic challenge for restoring vision. This corneal deficiency includes both classical ocular diseases (as chemical burns) and rare ocular diseases (as congenital aniridia and ocular cicatricial pemphigoid). Areas covered: Our understanding of limbal epithelial stem cells (LESCs) has increased the potential for treatment options. Pharmacological treatment strategies (as regenerating agent ophthalmic solutions) and especially surgical treatment strategies are available. Isolated LESCs can be produced by limbal primary cultures obtained from explants or cell suspensions. We review the latest cornea surgery techniques. Expert opinion: The adjunction of human limbal mesenchymal cells as a support for limbal stem cell primary cultures appears to be of great interest. Recently, human-induced pluripotent stem cells have allowed the generation of minicorneal organoids. This potential means of creating a three-dimensional cornea with in vitro maturation opens up important research areas for corneal regeneration therapy.
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Dates et versions

hal-03548056 , version 1 (29-01-2022)



Dominique Bremond-Gignac, Henri Copin, Moncef Ben Khalifa. Corneal epithelial stem cells for corneal injury. Expert Opinion on Biological Therapy, 2018, 18 (9), pp.997-1003. ⟨10.1080/14712598.2018.1508443⟩. ⟨hal-03548056⟩
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