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Relevance of oesophageal biopsies during graft-versus-host disease

Abstract : Introduction - Graft-versus-host disease (GVHD) is a complication of hematopoietic stem cell transplantation. It frequently affects the digestive tract. Oesophageal damage is not part of its typical clinical picture. The objective of this study was to determine whether oesophageallesions could be found in this condition. Material and methods. - Cases coded as GVH at the CHU of Amiens in anatomopathology were identified from 2004 to 2019. Each patient who had an oesophageal biopsy was included. The slides were re-read by 2 pathologists to assess the lesions. Results. - A total of 24 patients were included. A total of 79.1 % of the biopsies showe dinflammatory lesions: 25 % erosions, 37.5 % a cleavage between the lamina propria and squamous epithelium, 41.7 % a lichenoid inflammatory infiltrate, 54.1 % apoptotic cells and 54.1 % epithelial vacuolations. 25 % of the biopsies were classified as Lerner's grade 4 (used in dermatopathology to assess cutaneous GVH lesions), 12.5 % as grade 3, 25 % as grade 2, 16.7 % as grade-1, and 20.8 % of the biopsies did not show oesophageal GVH lesions. None of the histologicallesions observed were correlated with the prognosis, however erosions and epithelial cleavage were more frequently associated with death. Conclusion. - Lesions evocative and probably specific for acute GVH can be found in the esophagus. They could help and be part of the diagnosis. A protocol for oesophageal biopsy sampling, and the exclusion of other causes of esophagitis, should be performed in the future during suspicion of acute GVH. (C) 2021 Elsevier Masson SAS. All rights reserved.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03551240
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Soumis le : mardi 1 février 2022 - 15:13:26
Dernière modification le : vendredi 25 mars 2022 - 18:12:15

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Mickael Bendahman, Benjamin Ducloux-Lebon, Delphine Lebon, Mathurin Fumery, Adele Dujardin-Boisseau, et al.. Relevance of oesophageal biopsies during graft-versus-host disease. ANNALES DE PATHOLOGIE, 2021, 41 (3), pp.300-309. ⟨10.1016/j.annpat.2020.12.011⟩. ⟨hal-03551240⟩

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