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LSD instead of 251-NBOMe: The revival of LSD? A case report

Abstract : Observation. - We report a case of a 25-year-old man crushed by a train while he was returning from a rave party. The consumption of 251-NBOMe was rapidly evoked by people who had participated at the party. Materials and methods. - In this context, the post-mortem toxicological expertise was completed by a broad screening using high-resolution mass spectrometry detection (LC-HRMS). Three hundred NPS and metabolites (including 25B, 25C and 251-NBOMes) can be found with this method. A targeted screening in MRM mode was also performed on a smaller number of hallucinogens. Results. - The toxicological analyses were performed on blood and urine samples. Amphetamines, cocaine, cannabinoids and opiates were not detected. Ethanol was measured at 0.71 g/L and 1.59 g/L in blood and urine samples, respectively. The screening by LC-HRMS did not reveal the presence of NPS, including NBOMes. The targeted screening in MRM mode revealed the presence of LSD and its metabolite, the 2-oxo-3-hydroxy-LSD. LSD was quantified at 0.2 ng/mL in blood. Conclusion. - This case alerts on the frequent confusion between NBOMes and LSD and on the renewed interest for LSD due to the popularity of NBOMes. This case therefore encourages the prudence and research of all hallucinogenic substances, even when the context is evocative. (C) 2016 Societe Francaise de Toxicologic, Analytique. Published by Elsevier Masson SAS. All rights reserved.
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Soumis le : jeudi 10 février 2022 - 15:59:17
Dernière modification le : mercredi 24 août 2022 - 16:58:21

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Sandra Bodeau, Youssef Bennis, Oceane Regnaut, Nicolas Fabresse, Camille Richeval, et al.. LSD instead of 251-NBOMe: The revival of LSD? A case report. Toxicologie Analytique et Clinique, Elsevier, 2017, 29 (1), pp.139-143. ⟨10.1016/j.toxac.2016.12.007⟩. ⟨hal-03564815⟩

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