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Multicenter performance evaluation of the Unyvero IAI cartridge for detection of intra-abdominal infections

Abstract : Intra-abdominal infections (IAIs) are one of the most common type of infections in patients with sepsis and an important cause of death in intensive care units. Early detection and treatment are necessary to reduce patient complications and improve outcomes. The Unyvero IAI Application (Curetis GmbH) is the first automated assay to rapidly and simultaneously identify a large panel of bacteria, fungi, toxins, and antibiotic resistance markers directly from IAI-related samples. The assay was evaluated in four European clinical laboratories in comparison to routine microbiological practices. A total of 300 clinical samples were tested with an overall sensitivity of 89.3% and specificity of 99.5%, while time to results was reduced by an average of about 17h compared to identification (ID) results and 41h compared to full antibiotic susceptibility testing (AST) results. The Unyvero IAI was able to detect additional microorganisms compared with culture, in particular anaerobes, with most detections confirmed by sequencing. The most frequent resistance markers detected were mecA/mecC (n=25), aacA4 (n=20), and bla(CTX-M) (n=17) and carbapenemase genes were identified in nine specimens. Further studies are now required to determine the clinical impact of this new rapid test which could play a role in the successful treatment of IAI.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03577389
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Soumis le : mercredi 16 février 2022 - 16:37:25
Dernière modification le : vendredi 26 août 2022 - 17:50:30

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H. Ciesielczuk, M. Wilks, Sandrine Castelain, M. Choquet, M. Morotti, et al.. Multicenter performance evaluation of the Unyvero IAI cartridge for detection of intra-abdominal infections. European Journal of Clinical Microbiology and Infectious Diseases, Springer Verlag, 2018, 37 (11), pp.2107-2115. ⟨10.1007/s10096-018-3345-0⟩. ⟨hal-03577389⟩

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