Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Kinetics of SARS-CoV-2-Neutralising Antibodies of Residents of Long-Term Care Facilities

Abstract : Introduction Elderly residents of nursing homes (NHs) and long-term care units (LTCUs) have been shown to have a high risk of mortality and morbidity in cases of SARS-CoV-2 infection. The objective of this study was to examine the kinetics of neutralizing antibodies (NAbs) directed against the SARS-CoV-2 virus in residents of the NH and LTCU units of our University Hospital who were identified with positive serology after the first epidemic outbreak. Materials and Methods The participants included were sampled every three months for qualitative serological testing, as well as quantitative testing by neutralization tests using retroviral particles containing the S glycoprotein of SARS-CoV-2. Vaccination using the Comirnaty (Pfizer BNT162b2) vaccine begun before the last serological follow-up. Results The median NAb titer in June 2020 was 80 [40; 60] versus 40 [40; 160] three months later, showing a statistically significant decline (p < 0.007), but remained stable between the three- and six-month timepoints (p = 0.867). By nine months after vaccination, we observed a significant difference between vaccinated residents known to have positive serology before vaccination (SERO+, Vacc+) and those vaccinated without having previously shown COVID-19 seroconversion (SERO-, Vacc+), the latter group showing similar titers to the SERO+, Vacc- participants (p=0.166). The median antibody titer in SERO+, Vacc+ patients increased 15-fold following vaccination. Discussion Humoral immunity against SARS-CoV-2 appears to be persistent in elderly institutionalized patients, with a good post-vaccination response by residents who had already shown seroconversion but a notably diminished response by those who were seronegative before vaccination. To evaluate immunity in its entirety and elaborate a sound vaccination strategy, the cellular immune response via T cells specific to SARS-CoV-2 merits analysis, as this response is susceptible to being affected by immunosenescence.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-u-picardie.archives-ouvertes.fr/hal-03578461
Contributeur : Louise DESSAIVRE Connectez-vous pour contacter le contributeur
Soumis le : jeudi 17 février 2022 - 11:58:51
Dernière modification le : dimanche 28 août 2022 - 11:00:35

Lien texte intégral

Identifiants

Collections

Citation

Sophie Liabeuf, Jean-Luc Schmit, Jean-Philippe Lanoix, Sandrine Castelain, Frederic Bloch, et al.. Kinetics of SARS-CoV-2-Neutralising Antibodies of Residents of Long-Term Care Facilities. Journal of Nutrition, Health & Aging, Springer Verlag (Germany), 2022, 26 (1), pp.57-63. ⟨10.1007/s12603-021-1713-4⟩. ⟨hal-03578461⟩

Partager

Métriques

Consultations de la notice

20