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Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience

Abstract : Background: Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and severe cases might require heart transplantation. Objective: To investigate long-term outcomes after heart transplantation (HT) for peripartum cardiomyopathy (PPCM). Methods: Out of a single-center series of 1938 HT, 14 HT were performed for PPCM. We evaluated clinical characteristics, transplant-related complications, and long-term outcomes, in comparison with 28 sex-matched controls. Primary endpoint was death from any cause; secondary endpoints were transplant-related complications (rejection, infection, cardiac allograft vasculopathy). A value of p < 0.05 was considered of statistical significance. Results: PPCM patients and matched controls were comparable for most variables (all p values > 0.05), except for a higher use of inotropes at the time of HT in PPCM group (p = 0.03). During a median follow-up of 7.7 years, 16 patients died, 3 (21.5%) in PPCM group and 13 (46.5%) in control group. Mortality was significantly lower in PPCM group (p = 0.03). No significant difference was found in terms of transplant-related complications (p > 0.05). Conclusions: Long-term outcomes following HT for PPCM are favorable. Heart transplantation is a valuable option for PPCM patients who did not recover significantly under medical treatment.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03583845
Contributeur : Louise Dessaivre Connectez-vous pour contacter le contributeur
Soumis le : mardi 22 février 2022 - 09:50:18
Dernière modification le : jeudi 24 février 2022 - 03:36:15

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Nadia Bouabdallaoui, Pierre Demondion, Sylvestre Marechaux, Shaida Varnous, Guillaume Lebreton, et al.. Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience. ARQUIVOS BRASILEIROS DE CARDIOLOGIA, 2018, 110 (2), pp.181-187. ⟨10.5935/abc.20180014⟩. ⟨hal-03583845⟩

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