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Differential Determinants of Tubular Phosphate Reabsorption: Insights on Renal Excretion of Phosphates in Kidney Disease

Abstract : We assessed the tubular reabsorption of phosphate (TRP) and maximal renal threshold for phosphate reabsorption to glomerular filtration rate (TmPi/GFR) and their determinants in 64 stages 2-4 chronic kidney disease (CKD) patients in order to define the early changes in phosphate metabolism in CKD. In multivariable analysis, TmPi/GFR correlates were estimated GFR (eGFR), intact parathyroid hormone (iPTH), and hemoglobin (R-2 = 0.417), while TRP correlates were eGFR, iPTH, 24-h phosphaturia, and calcitriol (R-2 = 0.72). This suggests that TmPi/GFR and TRP, respectively, assess hemoglo-bin-phosphate and bowel-kidney phosphate regulation axis. Iron supplementation based on TmPi/GFR or earlier phosphate restriction based on TRP should be investigated in view of modifying clinical outcomes in CKD. (C) 2018 S. Karger AG, Basel
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Soumis le : mardi 22 février 2022 - 13:54:20
Dernière modification le : mercredi 23 mars 2022 - 15:51:11

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Nahid Tabibzadeh, Romuald Mentaverri, Maite Daroux, Rafik Mesbah, Alexia Delpierre, et al.. Differential Determinants of Tubular Phosphate Reabsorption: Insights on Renal Excretion of Phosphates in Kidney Disease. AMERICAN JOURNAL OF NEPHROLOGY, 2018, 47 (5), pp.300-303. ⟨10.1159/000488864⟩. ⟨hal-03584341⟩

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