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Article Dans Une Revue American Journal of Nephrology Année : 2018

Differential Determinants of Tubular Phosphate Reabsorption: Insights on Renal Excretion of Phosphates in Kidney Disease

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Résumé

We assessed the tubular reabsorption of phosphate (TRP) and maximal renal threshold for phosphate reabsorption to glomerular filtration rate (TmPi/GFR) and their determinants in 64 stages 2-4 chronic kidney disease (CKD) patients in order to define the early changes in phosphate metabolism in CKD. In multivariable analysis, TmPi/GFR correlates were estimated GFR (eGFR), intact parathyroid hormone (iPTH), and hemoglobin (R-2 = 0.417), while TRP correlates were eGFR, iPTH, 24-h phosphaturia, and calcitriol (R-2 = 0.72). This suggests that TmPi/GFR and TRP, respectively, assess hemoglo-bin-phosphate and bowel-kidney phosphate regulation axis. Iron supplementation based on TmPi/GFR or earlier phosphate restriction based on TRP should be investigated in view of modifying clinical outcomes in CKD. (C) 2018 S. Karger AG, Basel
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Dates et versions

hal-03584341 , version 1 (22-02-2022)

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Nahid Tabibzadeh, Romuald Mentaverri, Maite Daroux, Rafik Mesbah, Alexia Delpierre, et al.. Differential Determinants of Tubular Phosphate Reabsorption: Insights on Renal Excretion of Phosphates in Kidney Disease. American Journal of Nephrology, 2018, 47 (5), pp.300-303. ⟨10.1159/000488864⟩. ⟨hal-03584341⟩
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