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Practice guidelines Non-invasive diagnosis and follow-up of primary sclerosing cholangitis

Abstract : Primary sclerosing cholangitis (PSC) is a rare and chronic cholestatic liver disease of unknown cause commonly associated with inflammatory bowel disease (IBD) and characterized by progressive obliterative fibro-inflammation of the biliary tree. Although the natural course is highly variable, PSC is often progressive, leading to biliary cirrhosis and its complications. In addition, PSC is a condition harbouring broad neoplastic potential with increased susceptibility for the development of both biliary and colon cancer. As in other chronic liver diseases, non-invasive methods play a major role in the diagnosis and monitoring of PSC. MR cholangiography is the key exam for the diagnosis and has replaced diagnostic endoscopic retrograde cholangiopancreatography (ERCP). A strict and standardised protocol for carrying out MR cholangiography is recommended. Liver stiffness measured by FibroScan (R) correlates with the degree of liver fibrosis, has a prognostic value and should be repeated during follow-up. Invasive methods still play an important role, especially ERCP which is indicated for therapeutic purposes or for endo-biliary sample collection in suspected cholangiocarcinoma (following discussion in a multidisciplinary team meeting) and total colonoscopy which is recommended at the initial diagnosis of any PSC and annually in patients with IBD. (c) 2021 Elsevier Masson SAS. All rights reserved. .101775 SAS. All rights reserved.
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Soumis le : lundi 28 février 2022 - 11:11:00
Dernière modification le : mercredi 28 septembre 2022 - 16:20:12



Olivier Chazouilleres, Pascal Potier, Charlotte Bouzbib, Bertrand Hanslik, Alexandra Heurgue, et al.. Practice guidelines Non-invasive diagnosis and follow-up of primary sclerosing cholangitis. Clinics and Research in Hepatology and Gastroenterology, Elsevier, 2022, 46 (1), pp.101768. ⟨10.1016/j.clinre.2021⟩. ⟨hal-03590855⟩



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