Incidence and survival rates for adult malignant neuro-epithelial brain tumors in the Somme county (France): A retrospective, population-based study from 2003 to 2013

D. Bello Roufai (1) , P. Caillet (2, 3) , Bénédicte Lapôtre-Ledoux (1, 4) , Eric Trecherel (1) , L. Bauchet (5, 6) , Bruno Chauffert (7, 4) , O. Ganry (1, 4)

1 CHU Amiens-Picardie
2 IMRB - Institut Mondor de Recherche Biomédicale
3 SPHERE - MethodS in Patients-centered outcomes and HEalth ResEarch
4 CHIMERE - CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516
5 Service de Neurochirurgie [CHRU Montpellier]
6 INM - Institut des Neurosciences de Montpellier
7 Unité de génétique médicale et oncogénétique [CHU Amiens Picardie]

Aims: To describe the incidence and survival rates for neuro-epithelial primary brain tumors (NPBTs) in adults in the Somme county between 2003 and 2013. Methods: By analyzing the Somme Cancer Registry, we calculated the age-standardized incidence rates (ASRs) for NPBTs. Independent effects of age, gender and period of diagnosis on the incidence were evaluated in a Poisson regression analysis. A Cox proportional hazards model was used to adjust the overall survival rates for age, gender, histologic group and period. Results: Of the 257 registered NPBTs, 193 (75.1%) were astrocytic tumors. The subpopulations most affected by NPBTs were men (incidence rate ratio (IRR) [95% confidence interval (CI)] females/males = 0.7 [0.55-0.90], p < 0.001) and the elderly (IRR [95% CI] = 1.02 [1.01-1.03] per year increment, p < 0.001). The ASR [95% CI] was 4.5 [3.9-5.1] cases per 100,000 person-years. The increase in incidence [95%CI] between 2003 and 2013 was estimated to be 7.6% [3.4-11.2%] per year (p < 0.001). Survival improved significantly between the 2003-2008 period and the 2009-2013 period (hazard ratio [95%CI] = 0.70 [0.50-0.96], p = 0.03). Conclusion: We observed an increase in the incidence of NPBTs and in survival rates between 2009 and 2013. These increases might have been due to broader, earlier access to diagnostic tools and/or improvements in treatment procedures.

Mots clés: Population-based; Incidence; Survival; Standard of care; Neuro-epithelial primary brain tumor

Domaines: Cancer; Neurobiologie; Santé publique et épidémiologie

D. Bello Roufai, P. Caillet, Bénédicte Lapôtre-Ledoux, Eric Trecherel, L. Bauchet, et al.. Incidence and survival rates for adult malignant neuro-epithelial brain tumors in the Somme county (France): A retrospective, population-based study from 2003 to 2013. Journal of Cancer Policy, 2018, 15, Part A, pp.5-9. ⟨10.1016/j.jcpo.2017.11.001⟩. ⟨hal-03598675⟩