Impact and Relevance of the Unfolded Protein Response in HNSCC - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2019

Impact and Relevance of the Unfolded Protein Response in HNSCC

, (1, 2)
1
2

Résumé

Head and neck squamous cell carcinomas (HNSCC) encompass a heterogeneous group of solid tumors that arise from the upper aerodigestive tract. The tumor cells face multiple challenges including an acute demand of protein synthesis often driven by oncogene activation, limited nutrient and oxygen supply and exposure to chemo/radiotherapy, which forces them to develop adaptive mechanisms such as the Unfolded Protein Response (UPR). It is now well documented that the UPR, a homeostatic mechanism, is induced at different stages of cancer progression in response to intrinsic (oncogenic activation) or extrinsic (microenvironment) perturbations. This review will discuss the role of the UPR in HNSCC as well as in the key processes that characterize the physiology of HNSCC. The role of the UPR in the clinical context of HNSCC will also be addressed.

Dates et versions

hal-03599305 , version 1 (07-03-2022)

Identifiants

Citer

Olivier Pluquet, Antoine Galmiche. Impact and Relevance of the Unfolded Protein Response in HNSCC. International Journal of Molecular Sciences, 2019, 20 (11), ⟨10.3390/ijms20112654⟩. ⟨hal-03599305⟩

Collections

U-PICARDIE CHIMERE
8 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook Twitter LinkedIn More