HLA-B*15:47:01 allele with undefined serological equivalent considered as B Blank

Judith Desoutter (1, 2) , Valentine Jacob (1, 2) , Nicolas Guillaume (2)

1 CHU Amiens-Picardie
2 HEMATIM - HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666

We report a discordance between complement-dependent cytotoxicity and next-generation sequencing molecular typing revealing HLA-B*15:47:01 allele with undefined serological equivalent confirmed by high-level immunization against the B15 serotype. Due to the high-level immunization against HLA-B15 and B70 antigens, we considered the HLA-B*15:47:01 allele to be B Blank and not as B15 or B70 serological specificity.

Domaines: Sciences du Vivant [q-bio]

Judith Desoutter, Valentine Jacob, Nicolas Guillaume. HLA-B*15:47:01 allele with undefined serological equivalent considered as B Blank. International Journal of Immunogenetics, 2020, 47 (1), pp.65-66. ⟨10.1111/iji.12457⟩. ⟨hal-03606149⟩