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Cerebral Venous Thrombosis: Clinical, Radiological, Biological, and Etiological Characteristics of a French Prospective Cohort (FPCCVT)-Comparison With ISCVT Cohort

Sandrine Canaple 1, 2 Bertrand Roussel Nicolas Gaillard 3 Emilie Scavazza Veronique Le Cam Duchez 4 Aude Triquenot Bagan Isabelle Crassard 5 Ludovic Drouet 5 Marianne Barbieux-Guillot Raphael Marlu 6, 7 Emmanuelle Robinet-Borgomino Pierre-Emmanuel Morange 8, 9 Valerie Wolff 10 Lelia Grunebaum 11 Frederic Klapczynski Elisabeth Andre-Kerneis Fernando Pico 12 Brigitte Martin-Bastenaire Emmanuel Ellie 13 Fanny Menard Francois Rouanet 14 Genevieve Freyburger 15 Gaelle Godeneche Hong-An Allano Thierry Moulin 16 Guillaume Mourey 16 Laurent Derex 17 Micheline Berruyer Gwenaelle Runavot 18 Catherine Trichet 19 Fausto Viader 20 Agnes Le Querrec Thomas Tarek Husein Sophie Cluet-Dennetiere Francisco Macian-Montoro 21 Magali Donnard 22 Benoit Guillon 23 Catherine Ternisien 23 Mathieu Zuber 24 Sophie Laplanche 25 Philippe Tassan Jean-Yves Peeltier 
Abstract : Introduction: Cerebral venous thrombosis (CVT) is a rare disease with highly variable clinical presentation and outcome. Etiological assessment may be negative. The clinical and radiological presentation and evolution can be highly variable. The mechanisms involved in this variability remain unknown.Objective: The aim of this multicenter French study registered on ClinicalTrials.gov (NCT02013635) was therefore to prospectively recruit a cohort of patients with cerebral venous thrombosis (FPCCVT) in order to study thrombin generation and clot degradation, and to evaluate their influence on clinical radiological characteristics. The first part of the study was to compare our cohort with a reference cohort.Methods: This prospective, multicenter, French study was conducted from July 2011 to September 2016. Consecutive patients (aged >15 years) referred to the stroke units of 21 French centers and who had a diagnosis of symptomatic CVT were included. All patients gave their written informed consent. The diagnosis of CVT had to be confirmed by imaging. Clinical, radiological, biological, and etiological characteristics were recorded at baseline, at acute phase, at 3 months and at last follow-up visit. Thrombophilia screening and the choice of treatment were performed by the attending physician. All data were compared with data from the International Study on CVT published by Ferro et al.Results: Two hundred thirty-one patients were included: 117 (50.6%) had isolated intracranial hypertension, 96 (41.5%) had focal syndrome. During hospitalization, 229 (99.1%) patients received anticoagulant treatment. Median length of hospital stay was 10 days. Five patients died during hospitalization (2.2%). At 3 months, 216 patients (97.0%) had follow-up with neurological data based on an outpatient visit. The mean duration of antithrombotic treatment was 9 months, and the mean time to last follow-up was 10.5 months. At the end of follow-up, eight patients had died, and 26 patients were lost to follow-up. At least one risk factor was identified in 200 patients.Conclusions: We demonstrated that the FPCCVT cohort had radiological, biological, and etiological characteristics similar to the historical ISCVT cohort. Nevertheless, the initial clinical presentation was less severe in our study probably due to an improvement in diagnostic methods between the two studies.
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Soumis le : samedi 12 mars 2022 - 17:01:57
Dernière modification le : vendredi 9 septembre 2022 - 10:20:08

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Sandrine Canaple, Bertrand Roussel, Nicolas Gaillard, Emilie Scavazza, Veronique Le Cam Duchez, et al.. Cerebral Venous Thrombosis: Clinical, Radiological, Biological, and Etiological Characteristics of a French Prospective Cohort (FPCCVT)-Comparison With ISCVT Cohort. Frontiers in Neurology, Frontiers, 2021, 12, ⟨10.3389/fneur.2021.753110⟩. ⟨hal-03607029⟩

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